A0A6L7ISC4 · A0A6L7ISC4_9ACTN
- ProteinProbable endonuclease 4
- Genenfo
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids279 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Catalytic activity
Cofactor
Note: Binds 3 Zn2+ ions.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 67 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 107 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 142 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 142 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 176 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 179 | Zn2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 211 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 224 | Zn2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 226 | Zn2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 256 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | deoxyribonuclease IV (phage-T4-induced) activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | phosphoric diester hydrolase activity | |
Molecular Function | zinc ion binding | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable endonuclease 4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Coriobacteriia > Eggerthellales > Eggerthellaceae > Eggerthella
Accessions
- Primary accessionA0A6L7ISC4
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length279
- Mass (Da)30,337
- Last updated2020-10-07 v1
- Checksum3EC6AB5C92AD85B8
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP063310 EMBL· GenBank· DDBJ | QOS67661.1 EMBL· GenBank· DDBJ | Genomic DNA |