A0A6L7ISC4 · A0A6L7ISC4_9ACTN

  • Protein
    Probable endonuclease 4
  • Gene
    nfo
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

127920406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site67Zn2+ 1 (UniProtKB | ChEBI)
Binding site107Zn2+ 1 (UniProtKB | ChEBI)
Binding site142Zn2+ 1 (UniProtKB | ChEBI)
Binding site142Zn2+ 2 (UniProtKB | ChEBI)
Binding site176Zn2+ 2 (UniProtKB | ChEBI)
Binding site179Zn2+ 3 (UniProtKB | ChEBI)
Binding site211Zn2+ 2 (UniProtKB | ChEBI)
Binding site224Zn2+ 3 (UniProtKB | ChEBI)
Binding site226Zn2+ 3 (UniProtKB | ChEBI)
Binding site256Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      GS424_014275

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HF-1101
  • Taxonomic lineage
    Bacteria > Actinomycetota > Coriobacteriia > Eggerthellales > Eggerthellaceae > Eggerthella

Accessions

  • Primary accession
    A0A6L7ISC4

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-274Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    279
  • Mass (Da)
    30,337
  • Last updated
    2020-10-07 v1
  • Checksum
    3EC6AB5C92AD85B8
MFTIGCHLSSAKGYLHMAKDAVSIDATTFQFFTRNPRGGRAKAIDPKDVAAYAVYAPEHGITRILAHAPYTLNPASDKQQTRDFALMVLAEDLGRMEETPHQLYNMHPGSAVGQTHEEAIAKIADALNQSLLPVQTTTLLLETMAGKGSEIGGTFEELAAIIAQVELESHVGVCLDTCHVWDAGYDIVGDLDGVVEEFDRVIGLDRLRAIHLNDSQNARGSHKDRHARIGEGEIGFAALAAVTNHPKLRDLPFYLETPNDKLSGYAEEIAALREAHAIS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP063310
EMBL· GenBank· DDBJ
QOS67661.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp