A0A6H0WMS6 · A0A6H0WMS6_9BACI
- ProteinDiaminopimelate epimerase
- GenedapF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids284 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Catalytic activity
- (2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 14 | substrate | |||
Binding site | 67 | substrate | |||
Active site | 76 | Proton donor | |||
Binding site | 77-78 | substrate | |||
Binding site | 166 | substrate | |||
Site | 168 | Could be important to modulate the pK values of the two catalytic cysteine residues | |||
Binding site | 199 | substrate | |||
Site | 217 | Could be important to modulate the pK values of the two catalytic cysteine residues | |||
Binding site | 217-218 | substrate | |||
Active site | 226 | Proton acceptor | |||
Binding site | 227-228 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | diaminopimelate epimerase activity | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate epimerase
- EC number
- Short namesDAP epimerase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus
Accessions
- Primary accessionA0A6H0WMS6
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length284
- Mass (Da)30,835
- Last updated2021-02-10 v1
- Checksum1344817643EBEB4A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP048852 EMBL· GenBank· DDBJ | QIW81249.1 EMBL· GenBank· DDBJ | Genomic DNA |