A0A6A6RKL1 · A0A6A6RKL1_9PLEO

Function

function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.

Catalytic activity

Features

Showing features for binding site.

1728100200300400500600700
TypeIDPosition(s)Description
Binding site16-21GTP (UniProtKB | ChEBI)
Binding site38AMP (UniProtKB | ChEBI)
Binding site43AMP (UniProtKB | ChEBI)
Binding site64-66AMP (UniProtKB | ChEBI)
Binding site136-139AMP (UniProtKB | ChEBI)
Binding site143AMP (UniProtKB | ChEBI)
Binding site173GTP (UniProtKB | ChEBI)
Binding site182-183GTP (UniProtKB | ChEBI)
Binding site206AMP (UniProtKB | ChEBI)
Binding site217AMP (UniProtKB | ChEBI)
Binding site246GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentearly endosome
Cellular Componentmembrane
Cellular Componentmitochondrial matrix
Cellular Componentphagophore assembly site
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular Functionhydrolase activity
Molecular Functionnucleoside triphosphate adenylate kinase activity
Molecular Functionphosphatidylinositol binding
Biological ProcessADP biosynthetic process
Biological ProcessAMP metabolic process
Biological Processautophagy of mitochondrion
Biological Processendocytic recycling
Biological ProcessGTP metabolic process
Biological ProcessITP metabolic process
Biological Processphosphorylation
Biological Processpiecemeal microautophagy of the nucleus
Biological Processprotein transport
Biological Processreticulophagy

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP:AMP phosphotransferase, mitochondrial
  • EC number
  • Alternative names
    • Adenylate kinase 3
      (AK 3
      )

Gene names

    • Name
      ADK2
    • ORF names
      P280DRAFT_522360

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 473.64
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Massarinaceae > Massarina

Accessions

  • Primary accession
    A0A6A6RKL1

Proteomes

Subcellular Location

Endomembrane system
; Peripheral membrane protein
Mitochondrion matrix

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region37-66NMPbind
Region172-209LID
Region186-208Disordered
Region265-287Disordered
Compositional bias270-287Polar residues
Domain311-433PX
Coiled coil629-656

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. AK3 subfamily.
Belongs to the sorting nexin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    728
  • Mass (Da)
    81,689
  • Last updated
    2020-06-17 v1
  • Checksum
    7E63D268CF9BA094
MALSRAARIILVGAPGVGKGTQTDRLMKRFPDLSAISSGDLLRKNVRERTPLGIQAQAKMKAGALVPDTMILRLIINELTTRGWIQDSTLRPYNVYSSSLGMEMEDTVDSVLIPSTLRTSKYSYSDHPGASFILDGFPRTATQACQLDDIVPINLVVNLQTPSDIIIDRICNRWVHAPSGRVYNTTFNPPKVPGQDDVTGETLTRREDDDPEVWKARLKSFQDTNSSLLEHYDRLGVLWTVNGNSSDEITPQLFDEFGKRFGALDISPPAPTATTATTSTILTNRTSDRHRALGPERLRHRRMADDFSEGRLETTVGKPQKELPGTKDSYVSYLVSTKSDYQSFQRPDFSVRRRFTDFVFLWKQLIKEYPQCAIPPLPDKHKMEYVRGDRFGPDFTQRRAHSLHRFLKRMTLHPVLRRAALLISFLESPDWNQHMKGRSSRAPSASDQTGGGGIVDAIAESFVNTFTKVHKPDKRFIEVNERATKLTEDLSNVEKVVVRVARRQGDLEQDYGDLATQCQKLITLEPGVEGPLTSFASSVATTSLGFKALRDSTDQNYLTSLRDMDAFVGALKTLLRTRETKQLDFEALTDYLAKSAADRDLLASQHGAGMGASGFLRSKVEDFRGIDHEQARRQRVRKLEVEIERLTGEVESAKKATEAFDEHTVKEVADFERIKAVEFKDTLGEFADTHIEFFQGTVETWENFLADMQKQDEERRAAAAAADADAAS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias270-287Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU006800
EMBL· GenBank· DDBJ
KAF2636109.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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