A0A6A6RKL1 · A0A6A6RKL1_9PLEO
- ProteinGTP:AMP phosphotransferase, mitochondrial
- GeneADK2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids728 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
Catalytic activity
- a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 16-21 | GTP (UniProtKB | ChEBI) | |||
Binding site | 38 | AMP (UniProtKB | ChEBI) | |||
Binding site | 43 | AMP (UniProtKB | ChEBI) | |||
Binding site | 64-66 | AMP (UniProtKB | ChEBI) | |||
Binding site | 136-139 | AMP (UniProtKB | ChEBI) | |||
Binding site | 143 | AMP (UniProtKB | ChEBI) | |||
Binding site | 173 | GTP (UniProtKB | ChEBI) | |||
Binding site | 182-183 | GTP (UniProtKB | ChEBI) | |||
Binding site | 206 | AMP (UniProtKB | ChEBI) | |||
Binding site | 217 | AMP (UniProtKB | ChEBI) | |||
Binding site | 246 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | membrane | |
Cellular Component | mitochondrial matrix | |
Cellular Component | phagophore assembly site | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | nucleoside triphosphate adenylate kinase activity | |
Molecular Function | phosphatidylinositol binding | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | autophagy of mitochondrion | |
Biological Process | endocytic recycling | |
Biological Process | GTP metabolic process | |
Biological Process | ITP metabolic process | |
Biological Process | phosphorylation | |
Biological Process | piecemeal microautophagy of the nucleus | |
Biological Process | protein transport | |
Biological Process | reticulophagy |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP:AMP phosphotransferase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Massarinaceae > Massarina
Accessions
- Primary accessionA0A6A6RKL1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endomembrane system ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 37-66 | NMPbind | |||
Region | 172-209 | LID | |||
Region | 186-208 | Disordered | |||
Region | 265-287 | Disordered | |||
Compositional bias | 270-287 | Polar residues | |||
Domain | 311-433 | PX | |||
Coiled coil | 629-656 | ||||
Domain
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
Sequence similarities
Belongs to the adenylate kinase family. AK3 subfamily.
Belongs to the sorting nexin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length728
- Mass (Da)81,689
- Last updated2020-06-17 v1
- Checksum7E63D268CF9BA094
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 270-287 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MU006800 EMBL· GenBank· DDBJ | KAF2636109.1 EMBL· GenBank· DDBJ | Genomic DNA |