A0A5K7S375 · A0A5K7S375_9BACT

  • Protein
    4-hydroxy-tetrahydrodipicolinate synthase
  • Gene
    dapA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

Caution

Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site47Part of a proton relay during catalysis
Binding site48pyruvate (UniProtKB | ChEBI)
Site110Part of a proton relay during catalysis
Active site136Proton donor/acceptor
Active site165Schiff-base intermediate with substrate
Binding site207pyruvate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate synthase activity
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate synthase
  • EC number
  • Short names
    HTPA synthase

Gene names

    • Name
      dapA
    • ORF names
      AQPE_0051

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MeG22
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Marinilabiliales > Prolixibacteraceae > Aquipluma

Accessions

  • Primary accession
    A0A5K7S375

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer; dimer of dimers.

Family & Domains

Sequence similarities

Belongs to the DapA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    31,593
  • Last updated
    2020-02-26 v1
  • MD5 Checksum
    204817B56DAC110AA7BFDA0966D495A5
MTHPFTGAGVALITPFNEDMSVDYSALERLVEDQISGGIDYLVVLGTTGETPALSDEEKKEIVRFVIEKNAGRLKIVVGIGSNNTLALVHSIQNYNFEGIDAILSVTPYYNKPTQEGLFQHFKAVVEASPVPVILYNVPGRTGVNMEAETTLRIARLSEKVVGIKEACGVLAQFTKIINEAPSYFKVISGDDGLTLPSIVIGSIGVISVIANALPKKLSQLTRASLEGNMPLATQLHLEMAEMLKLIFKEGSPAGVKALMEIMGTVKNQVRLPNVPVSAATFSLIENELKLIN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018694
EMBL· GenBank· DDBJ
BBE15915.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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