A0A5K7S2E2 · A0A5K7S2E2_9BACT

  • Protein
    Sulfite reductase [NADPH] hemoprotein beta-component
  • Gene
    cysI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.
siroheme (UniProtKB | Rhea| CHEBI:60052 )

Note: Binds 1 siroheme per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site431[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site437[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site476[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site480[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site480Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentsulfite reductase complex (NADPH)
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionsulfite reductase (ferredoxin) activity
Molecular Functionsulfite reductase (NADPH) activity
Biological Processcysteine biosynthetic process
Biological Processhydrogen sulfide biosynthetic process
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfite reductase [NADPH] hemoprotein beta-component
  • EC number
  • Short names
    SiR-HP
    ; SiRHP

Gene names

    • Name
      cysI
    • ORF names
      AQPE_0018

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MeG22
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Marinilabiliales > Prolixibacteraceae > Aquipluma

Accessions

  • Primary accession
    A0A5K7S2E2

Proteomes

Subcellular Location

Interaction

Subunit

Alpha8-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain74-130Nitrite/Sulfite reductase ferredoxin-like
Domain170-324Nitrite/sulphite reductase 4Fe-4S
Domain349-412Nitrite/Sulfite reductase ferredoxin-like

Sequence similarities

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    566
  • Mass (Da)
    63,723
  • Last updated
    2020-02-26 v1
  • MD5 Checksum
    79E8D6C9E5C73D7ECACE7CF6ACAEED32
MNDTINWDELSELERIKYESNYLRGTLVESLADPITGSIAYADTQLSKFHGLYQQFDRDLEKERKRQKLEPAYSFLIRVRLPGGVVTPKQWLQMDEISEQYANHTLKLTTRQAFQLHGVIKSNLKKTIQGINTALLDTIAACGDVNRNVMSHPNPSESELHAEVYETARRISEHLLPSTTAYHEIWLDQKLIADSKKDVEPIYGDRYLPRKFKIAIAIPPYNDSDVFSQDLGFIAIVGNNRIIGYNVAVGGGMGTTFGMPETYPRLAEVIGFCTPEQVIDVAEKVVLVQRDNGNRQNRKISRLKYTIDRLGIEAFKAELYNYLGYELQEAKPYAFTRNGDRLGWKKGTDSKWSLSLFVEGGRVADRNGFNLKSALREVAQHINGQFILTGNQNLIIANVTADEKNTVGEILKNNGVLPGEISGLRQNSIACVALNTCSLAFAEAERYLPSLVSKIESILNQHDLFQEEIVIRMTGCPNGCGRPYLAEIGFVGKSEGHYNLYLGGNFNGTRLNTLYKETLTEDDILAELDPIIADYATNRNTGEKFGDFVIRKQYVNEIVKGSDFRH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018694
EMBL· GenBank· DDBJ
BBE15882.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help