A0A5C4VII7 · A0A5C4VII7_9ACTN

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site76substrate
Binding site215-217substrate
Binding site224Mn2+ (UniProtKB | ChEBI)
Binding site244Mn2+ (UniProtKB | ChEBI)
Binding site266substrate
Binding site267-272GTP (UniProtKB | ChEBI)
Active site268
Binding site291Mn2+ (UniProtKB | ChEBI)
Binding site381-383substrate
Binding site383GTP (UniProtKB | ChEBI)
Binding site414GTP (UniProtKB | ChEBI)
Binding site508-511GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      FH608_031725

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PA1-10
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Nonomuraea

Accessions

  • Primary accession
    A0A5C4VII7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-236Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain240-593Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    597
  • Mass (Da)
    66,054
  • Last updated
    2019-11-13 v1
  • Checksum
    FC2B4A66842C5560
MSVSVEVPAPTSNRELAAWVKEIAALTQPDRIEWCDGSEEEWTRLTNLLVEQGTFTRLAARPNSFYAKSDPGDVARVEDRTFICSEREEDAGPTNNWVAPDEMRRTFGTLFKGCMRGRTMYVVPFCMGPLGGEISQLGVEITDSPYVAVSMRVMTRMGDRALRRIEERGSFVKAVHSVGAPLEPGQEDVPWPCNPTKYISHFPETREIWSYGSGYGGNALLGKKCYALRIASAMARDEGWLAEHMLILKLTPPSGETRYIAAAFPSACGKTNLAMLQPTIPGWKVETIGDDIAWMRFGDDGRLYAINPEAGFFGVAPGTGEVTNANAIRTLWGNSIFTNVALTDDGDVWWEGLTAKPPAHLTDWKGRSWTPESGEPAAHPNARFTTPASQCPTIAPEWQDPKGVPISAILFGGRRATAVPLVTESLSWEHGVFLGANVASEKTAAAEGKVGELRYDPFAMLPFCGYNMGDYFGHWLDVGRRAGAKLPRIYYVNWFRKNADGKFIWPGFGENSRVLKWIVDRLNGEAKAVPTPIGLLPAELDTEGLDLTDEDLRTLLSVDREAWREEASLIPAHFDKFGSHLPKELWDEYNALLDRLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VDLX02000013
EMBL· GenBank· DDBJ
KAB8191173.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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