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A0A5C2HEJ7 · A0A5C2HEJ7_9BACT

  • Protein
    Aspartate-semialdehyde dehydrogenase
  • Gene
    asd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-15NADP+ (UniProtKB | ChEBI)
Binding site40-41NADP+ (UniProtKB | ChEBI)
Binding site102phosphate (UniProtKB | ChEBI)
Active site133Acyl-thioester intermediate
Binding site160substrate
Binding site163-164NADP+ (UniProtKB | ChEBI)
Binding site240substrate
Active site247Proton acceptor
Binding site322NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      APAC_1724

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LMG 26638
  • Taxonomic lineage
    Bacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Arcobacteraceae > Malaciobacter

Accessions

  • Primary accession
    A0A5C2HEJ7

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    345
  • Mass (Da)
    38,150
  • Last updated
    2019-11-13 v1
  • MD5 Checksum
    063F7B45E69932C064D0BED3EEF1B191
MRKFNVAVVGATGAVGEELFRVLAEYDFPINNLVPLASSRSAGSTIEFKNKEYTVKELTETCFEENDVEIAFFSAGGSVSEKFAKFAVEAGAVVIDNTSHFRMDPNVPLVVPEVNPEDIVNWRETGIIANPNCSTIQMVLSLKPLDDLYGIKRVDVSTYQAVSGAGKTGMEELVKQMQDFFAFKLDETEIKAFAHQIALNVIPQIDVAQPNGFTKEEMKMVLETQKIMHKELQVAATCVRVPVLRSHSESITVTFEDGVEVDVDAARDALAAFDDVEVIDDLANNAYPMPIVSTDTDITYVGRIRRDVYAPNVLHYFNVADQVRVGAATNAVRIGLKWIEMENDI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP035928
EMBL· GenBank· DDBJ
QEP34812.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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