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A0A4Y1REE6 · A0A4Y1REE6_PRUDU

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Biological Processhomoserine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processmethionine biosynthetic process
Biological Processphosphorylation
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Submitted names
    • Aspartate kinase-homoserine dehydrogenase ii

Gene names

    • ORF names
      Prudu_013279

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Rosaceae > Amygdaloideae > Amygdaleae > Prunus

Accessions

  • Primary accession
    A0A4Y1REE6

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain366-441ACT
Domain447-524ACT

Sequence similarities

In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    894
  • Mass (Da)
    98,112
  • Last updated
    2019-09-18 v1
  • MD5 Checksum
    1F93510CC0E42443D0387E88BA5B95CD
MAMGFVSGLERKMTLKSRIFASVTDTPVNTSPEKVQLPKGDTWSVHKFGGTCMGSSERIKNVAKIVLSDDSERKFIVVSAMSKVTDMIYDLIYKAQSRDDSYLSALDAVLEKHRSTAFDLLDGDELGSFLAQLNHDISNLKAMLRAIYIAGHATESFTDFVVGHGELWSAQMLSCVVRKNGVDCNWMDTREVLIVNPTSSNQVDPDFKESEERLEIWYSKNPSKTIVATGFIASTPKNIPTTLKRDGSDFSAAIMGALFRARQVTIWTDVDGVYSADPRKVSEAVILKTLSYQEAWEMSYFGANVLHPRTIIPVMRYDIPIIIRNVFNLAVPGTKICRSTEDEDGQGLESFVKGFATIDNLALVNVEGTGMAGVPGTASTIFSAVKDVGANVIMISQASSEHSVCFAVPEKEVNAVSELLKSRFREALNAGRLSQVQVIPNCSILAAVGQKMASTPGVSATLFNALAKANINVRAIAQGCSEYNITVVVKREDCIRALRAVHSRFYLSRTTIAMGIIGPGLIGGTLLDQLRDQTATLKEEFNIDLRVMGITGSRTMLLSEAGIDLSRWKELQKEKGVVADMEKFVQHIHGNHFIPNTVLVDCTADSSIASHYYDWLRKGIHVVTPNKKANSGPLDQYLKLRALQRQSYTHYFYEATVGAGLPIINTLQGLLETGDKILRIEGIFSGTLSYIFNNFIGRRTFSEVVAEAKQAGYTEPDPRDDLSGTDVCRKVIILARESGLKLELSDIPVESLVPEPLKDSASAEEFMQKLPQFDHDLAKKRQIAEDAGQEYANPILYSCSGFTSVLRYVGVVDMVNQEGAVKLQTYKNDHPFAQLSGADNIIAFTTTRYKDQPLIVRGPGAGAEVTAGGVFSDILRLASYLGARHSGKHVARRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP019301
EMBL· GenBank· DDBJ
BBH02639.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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