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A0A4S1H189 · A0A4S1H189_UNCXX

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site10-15NAD+ (UniProtKB | ChEBI)
Binding site14NADPH (UniProtKB | ChEBI)
Binding site35NADPH (UniProtKB | ChEBI)
Binding site108NADPH (UniProtKB | ChEBI)
Binding site108sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site108substrate
Binding site136sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site140NAD+ (UniProtKB | ChEBI)
Binding site140NADPH (UniProtKB | ChEBI)
Active site191Proton acceptor
Binding site191sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site244sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site254sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255NAD+ (UniProtKB | ChEBI)
Binding site255NADPH (UniProtKB | ChEBI)
Binding site255sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site255-256substrate
Binding site256sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site275NADPH (UniProtKB | ChEBI)
Binding site277NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      EN811_20405

Organism names

Accessions

  • Primary accession
    A0A4S1H189

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-159Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain180-316Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    33,783
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    D1AB069388566EE1636318B0241475E2
MQREKIVVIGAGAFGTALAVVIALENRHDVILLGRDPSLMADLRSDRVHEAALPGVELPDVLEFSAEPDVLTSAGIVLFAMPSQAHADAARHYRPYLANDSIVVTCAKGIDRSSGRLLTELLEAELPRHPIAVLSGPGFAADIARGLPTAMAIAAEDATIAERLATTISGKTFRLYASTDRIGVQLGGALKNILAIAAGIVEGAGLGDSARAALISRGLAEMSRLIVAMGGKADTVRGLSGLGDLVLTATSHQSRNLRFGIALGRGNGKDMSGGLVEGAFAAAVAARLGESHTVDMPVTEAVAAIIDGNLDVASAMQQLMTRPITTE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SRTJ01000006
EMBL· GenBank· DDBJ
TGV45816.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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