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A0A4S1GXJ7 · A0A4S1GXJ7_UNCXX

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site14Mg2+ (UniProtKB | ChEBI)
Site19Substrate discrimination
Binding site108Mg2+ (UniProtKB | ChEBI)
Active site109

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • ORF names
      EN811_23195

Organism names

Accessions

  • Primary accession
    A0A4S1GXJ7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-190UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    363
  • Mass (Da)
    39,980
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    17B200E3328B61A4FA0AC1B93E7FD8C7
MAQAEHTKKIIHVDMDAFYASVEQRDNPELRGKPIAVGGAAARGVVAAASYEARKFGVHSAMPSVTAARKCPDLIFVKPRFEVYHAISQQIRKVFSEYTPLFEPLSLDEAYLDVTKNLKDMPIATEIALEIREKIKEATGLNASAGISYNKFLAKMASDLNKPNGQAVITPKNGPAFVEGLAVKKFHGVGPATAEKMHRLGIETGAELKAQSMQFLTQHFGKMGPYFYGIARGIDERQVQPDRVRKSVGAEDTFVQDIDDLVSATNELKPLVEKVWRYCETKGFSGKTITVKVKYFDFTQTTRSKSNTQPFGNCGELLHAAIGLLASVYPFKRSVRLLGVTLSSLVDEDRVGIGYQPQLGFDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SRTJ01000008
EMBL· GenBank· DDBJ
TGV44376.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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