A0A4R8X649 · A0A4R8X649_9MICO
- ProteinPantothenate synthetase
- GenepanC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids311 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 60-67 | ATP (UniProtKB | ChEBI) | |||
Active site | 67 | Proton donor | |||
Binding site | 91 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 91 | beta-alanine (UniProtKB | ChEBI) | |||
Binding site | 178-181 | ATP (UniProtKB | ChEBI) | |||
Binding site | 184 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 207 | ATP (UniProtKB | ChEBI) | |||
Binding site | 215-218 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Cryobacterium
Accessions
- Primary accessionA0A4R8X649
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)32,677
- Last updated2019-07-31 v1
- MD5 ChecksumAE76D377C8B2CA612761263958A1DF7A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
SOGE01000038 EMBL· GenBank· DDBJ | TFC65143.1 EMBL· GenBank· DDBJ | Genomic DNA |