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A0A4R8X649 · A0A4R8X649_9MICO

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site60-67ATP (UniProtKB | ChEBI)
Active site67Proton donor
Binding site91(R)-pantoate (UniProtKB | ChEBI)
Binding site91beta-alanine (UniProtKB | ChEBI)
Binding site178-181ATP (UniProtKB | ChEBI)
Binding site184(R)-pantoate (UniProtKB | ChEBI)
Binding site207ATP (UniProtKB | ChEBI)
Binding site215-218ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      E3O54_13345

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TMT2-4
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Cryobacterium

Accessions

  • Primary accession
    A0A4R8X649

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    311
  • Mass (Da)
    32,677
  • Last updated
    2019-07-31 v1
  • MD5 Checksum
    AE76D377C8B2CA612761263958A1DF7A
MTQPQHTGGRVNVLTKPAVIGSIEELRSRLTDAQSRIESARAGRGEAGLGRPRIVLVPTMGALHAGHLTLVRRARSLGDIVVVSIFVNPLQFGVGEDLGSYPRMLEADVAALAAEGVPFVFAPTSQLMYPDGAASTRVVAGAVGSLFEGAARPGHFDGMLTVVAKLFNIVGPDVAVFGQKDAQQVFLVERMLADLNFRTRIEVVPIVREDGGLALSSRNRALEPAQRAAARALSAGLEAAASVAAQGVGAALQAAHARIDVQPLLKLDYLVVVDPRTFLPVGGEHHGPARMLVAALVGHTRLIDNVALDLP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SOGE01000038
EMBL· GenBank· DDBJ
TFC65143.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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