A0A443SQV8 · A0A443SQV8_9ACAR
- ProteinSerine hydroxymethyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids478 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Interconversion of serine and glycine.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | cobalt ion binding | |
Molecular Function | glycine hydroxymethyltransferase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | mRNA 5'-UTR binding | |
Molecular Function | mRNA regulatory element binding translation repressor activity | |
Molecular Function | protein homodimerization activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | serine binding | |
Molecular Function | zinc ion binding | |
Biological Process | folic acid metabolic process | |
Biological Process | glycine biosynthetic process from serine | |
Biological Process | L-serine catabolic process | |
Biological Process | methylation | |
Biological Process | protein homotetramerization | |
Biological Process | purine nucleobase biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine hydroxymethyltransferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Trombidiformes > Prostigmata > Anystina > Parasitengona > Trombiculoidea > Trombiculidae > Leptotrombidium
Accessions
- Primary accessionA0A443SQV8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 253 | N6-(pyridoxal phosphate)lysine | |||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)53,185
- Last updated2019-05-08 v1
- MD5 Checksum007D129BB6C1EEDEF16DE6332F238CDD
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NCKV01000714 EMBL· GenBank· DDBJ | RWS29926.1 EMBL· GenBank· DDBJ | Genomic DNA |