A0A443RWN7 · A0A443RWN7_9ACAR

  • Protein
    glycerophosphocholine cholinephosphodiesterase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.
    EC:3.1.4.38 (UniProtKB | ENZYME | Rhea)
  • sphing-4-enine-phosphocholine + H2O = sphing-4-enine + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + phosphocholine + H+
    This reaction proceeds in the forward direction.
  • glycero-2-phosphocholine + H2O = phosphocholine + glycerol + H+
    This reaction proceeds in the forward direction.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentmembrane
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glycerophosphocholine cholinephosphodiesterase
  • EC number
  • Alternative names
    • Choline-specific glycerophosphodiester phosphodiesterase
    • Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Gene names

    • ORF names
      B4U80_03599

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UoL-UT
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Acariformes > Trombidiformes > Prostigmata > Anystina > Parasitengona > Trombiculoidea > Trombiculidae > Leptotrombidium

Accessions

  • Primary accession
    A0A443RWN7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    138
  • Mass (Da)
    16,049
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    8EE71F8A3E3FF1084C46AF40C3620CA2
MAFESKKFRLIAFMILVLVLFVILAIFAVLKYKVTTEKGKKLLVIMIDGVRHDYPDRESNLTAFQKLTSDGVKAEYLEPVFPSSTYPNWYAIATGLFPETNGFVANRMYDELRNDFFLMSPHPNASHKHWWNKAEPIW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue138

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NCKV01025065
EMBL· GenBank· DDBJ
RWS19548.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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