A0A418KGE0 · A0A418KGE0_9ACTN

  • Protein
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site78-81substrate
Binding site100substrate
Binding site101Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Alternative names
    • Oxaloacetate decarboxylase
    • Regulator of ribonuclease activity homolog
    • RraA-like protein

Gene names

    • ORF names
      DY240_30440

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NEAU-YY265
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Jiangellales > Jiangellaceae > Jiangella

Accessions

  • Primary accession
    A0A418KGE0

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    23,909
  • Last updated
    2019-05-08 v1
  • MD5 Checksum
    D2CBDDD6EFB502B407CD2615D520B52A
MFENLTTAHLADACLRAGVPVRCASLPPVVPGWRAAGRALPCVHVGSVDVFLEAYESAGPGDVLVVDNGGRGDEACVGDLAVLEARAAGLSGVVVWGLHRDTADIRAIGLPVFSLGALPTGPQRLDPRPADGGLVRAAVAGFEVTRSDAILADDDGVVVVPFDRAEELTALAAAIRDTERQQAELVRDGTTLRDQLRFGDYLARRRTEPELTFRQHLRSIGGAIEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QUAL01000438
EMBL· GenBank· DDBJ
RIQ10968.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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