A0A418KGE0 · A0A418KGE0_9ACTN
- ProteinPutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids226 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
Catalytic activity
- 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 78-81 | substrate | |||
Binding site | 100 | substrate | |||
Binding site | 101 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | oxaloacetate decarboxylase activity |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Jiangellales > Jiangellaceae > Jiangella
Accessions
- Primary accessionA0A418KGE0
Proteomes
Interaction
Subunit
Homotrimer.
Structure
Sequence
- Sequence statusComplete
- Length226
- Mass (Da)23,909
- Last updated2019-05-08 v1
- MD5 ChecksumD2CBDDD6EFB502B407CD2615D520B52A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QUAL01000438 EMBL· GenBank· DDBJ | RIQ10968.1 EMBL· GenBank· DDBJ | Genomic DNA |