A0A3R9P8R6 · A0A3R9P8R6_9BACI
- Protein4-hydroxy-tetrahydrodipicolinate reductase
- GenedapB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids267 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Catalytic activity
- (S)-2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-16 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 46 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 100-102 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 126-129 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 156 | Proton donor/acceptor | |||
Binding site | 157 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | |||
Active site | 160 | Proton donor | |||
Binding site | 166-167 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate reductase | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate reductase
- EC number
- Short namesHTPA reductase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae
Accessions
- Primary accessionA0A3R9P8R6
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-129 | Dihydrodipicolinate reductase N-terminal | |||
Domain | 132-266 | Dihydrodipicolinate reductase C-terminal | |||
Region | 176-195 | Disordered | |||
Compositional bias | 181-195 | Basic and acidic residues | |||
Sequence similarities
Belongs to the DapB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length267
- Mass (Da)29,356
- Last updated2019-04-10 v1
- MD5 ChecksumC6D128301E02B57415AA02B910A1E836
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 181-195 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
RBVX01000006 EMBL· GenBank· DDBJ | RSL33876.1 EMBL· GenBank· DDBJ | Genomic DNA |