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A0A3R9P8R6 · A0A3R9P8R6_9BACI

  • Protein
    4-hydroxy-tetrahydrodipicolinate reductase
  • Gene
    dapB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site11-16NAD+ (UniProtKB | ChEBI)
Binding site46NADP+ (UniProtKB | ChEBI)
Binding site100-102NAD+ (UniProtKB | ChEBI)
Binding site126-129NAD+ (UniProtKB | ChEBI)
Active site156Proton donor/acceptor
Binding site157(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site160Proton donor
Binding site166-167(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      D7Z54_08860

Organism names

Accessions

  • Primary accession
    A0A3R9P8R6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain6-129Dihydrodipicolinate reductase N-terminal
Domain132-266Dihydrodipicolinate reductase C-terminal
Region176-195Disordered
Compositional bias181-195Basic and acidic residues

Sequence similarities

Belongs to the DapB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    267
  • Mass (Da)
    29,356
  • Last updated
    2019-04-10 v1
  • MD5 Checksum
    C6D128301E02B57415AA02B910A1E836
MSKVTKIIIAGPRGKMGKETVQLVRETEEFQLEAVVDSKNAGKMLKELPNMPDEQAPVYDDMKVCLEETEADVLIDLTTPAAGKKHLELALDYNVRPVVGTTGFSEEDVERLRDKAEDKEIGAIIAPNFAVGAILMMKLAQMTAKYFSDAEIIEMHHDNKLDAPSGTATKTASLINEVRPHKTQGHPDEKEDLDGARGADIDGLRIHSVRLPGLIAHQEILFGGSGQTLKIRHDSMNRQSFMPGVKLAVENVLSLKTLVYGLENIMD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias181-195Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
RBVX01000006
EMBL· GenBank· DDBJ
RSL33876.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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