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A0A3Q4GML1 · A0A3Q4GML1_NEOBR

Function

function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.

Catalytic activity

  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.1.93 (UniProtKB | ENZYME | Rhea)
  • 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+
    This reaction proceeds in the forward direction.
    EC:2.7.1.107 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; glycerolipid metabolism.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionalkylglycerol kinase activity
Molecular FunctionATP binding
Molecular FunctionATP-dependent diacylglycerol kinase activity
Molecular Functioncalcium ion binding
Biological Processdiacylglycerol metabolic process
Biological Processintracellular signal transduction
Biological Processlipid phosphorylation
Biological Processphospholipase C-activating G protein-coupled receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diacylglycerol kinase
  • EC number
  • Short names
    DAG kinase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Lamprologini > Neolamprologus

Accessions

  • Primary accession
    A0A3Q4GML1

Proteomes

Subcellular Location

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain113-148EF-hand
Domain158-193EF-hand
Domain207-257Phorbol-ester/DAG-type
Domain272-322Phorbol-ester/DAG-type
Domain376-510DAGKc

Sequence similarities

Belongs to the eukaryotic diacylglycerol kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    731
  • Mass (Da)
    81,944
  • Last updated
    2019-04-10 v1
  • MD5 Checksum
    DEB4C77B26DC1EAA4363F4BD093A14B7
MSSPTNPEVKELNPVDFIQLQQYIEYNNLKVKDVLREFYADGSLARHRHGECINEEGFRLFLKTYLEVEDFPVDLCQRLFRSFQNSEPGQEDSTKEVFLKDVSCYFSLLEDGQPRDKLEFAFRLYDRDGNGVLDSSEVDRIIAQMMHAAEYLDWDVSELKPVLKDMMTAIDADSSGTVSLDEWVQGGMNNVPLLVLLGLKMTQKDGQHLWRMKNFNKPVYCNVCHSMLLGLRKQGLCCTSCKYTVHGRCANKNPAPCARTYVKSKKEIGVSTHDWVSGNCDSRKCDKCQKKIKSLQGLTGKHCVWCHTMRHDQCVDQESTQCTCGLLRDHILPPWAIYPVIKERPNNVKNGCSGSGDDSELNTTPDGQVLQICPVLNAHPLLVFVNPKSGGKQGERVLRKFQFLLNPRQVYNLSNGGPGPGLSFFRNLKEYRILVCGGDGTVGWILDAIDKGNLLVRPPVAVLPLGTGNDLARCLRWGGGYDGEDLNRILKDIEGSSQVLMDRWSVQVITDENQEEGDPVPYEIINNYFSIGVDASIAHRFHTMREKHPQKFNSRMKNKLWYFEFATSETISASCKKLSENLTIECCGTALDLSGVSLEGVAILNIPSMHGGSNLWGETKKVDTKGLTAQEEPEVIVNPEILKVTSQDLSDRRLEVVGLEGAMEMGQIYTGLKSAVRLAKTSQITIRTKKALPMQIDGEPWMQPPCTIQITHKNQACMLMGPPAKPSGFFK

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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