A0A3P9H3T2 · A0A3P9H3T2_ORYLA

Function

function

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA).

Catalytic activity

  • (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.51 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism.
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionacyltransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
  • EC number
  • Alternative names
    • 1-acylglycerol-3-phosphate O-acyltransferase 4
    • Lysophosphatidic acid acyltransferase delta

Organism names

  • Taxonomic identifier
  • Strains
    • Hd-rR
    • HSOK
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A3P9H3T2

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane37-69Helical
Transmembrane154-172Helical
Transmembrane339-358Helical
Transmembrane364-384Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain118-240Phospholipid/glycerol acyltransferase

Sequence similarities

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    408
  • Mass (Da)
    46,868
  • Last updated
    2019-02-13 v1
  • Checksum
    96323BD49FBB911D
MTHNSWYVNKKIMFTFRVNVVFSRLSWRMGLLSTLKSLFICHLIIGYVFLVSGILINLLQVCTLPVWLVSKQLARRINIRLGYCIASQVVAVLEWWSGTECTLYTDPKSYPLYGKENAIVLLNHNFEIDFLCGWTFCERFGVLGSSKVLAKQELAYVPVIGWMWYFLEIVFCKRKWEEDRRLVAQSLQNLRDYPENYWFLLFCEGTRFTPEKHQASMQVAESKGLPKLKYHLLPRTKGFWMTVQNLRGTVSAVYDSTLNFRDNETPTMLGVLNGKKYHADLYVRRIPLELIPEEEKECAAWLHKLYQEKDELQGAYEKTGLFPGPKTSPPRQLRTLMNWLFWSCVVLYPLGLMLTHVISSGSALTIIAAVVVSSAASVAVRWMIGQTEIGKGSKYGNREVPPNTNGSS

Genome annotation databases

Similar Proteins

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