A0A3N4KMP6 · A0A3N4KMP6_9PEZI

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10-15ITP (UniProtKB | ChEBI)
Binding site39Mg2+ (UniProtKB | ChEBI)
Binding site51ITP (UniProtKB | ChEBI)
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site67-68ITP (UniProtKB | ChEBI)
Binding site142-145ITP (UniProtKB | ChEBI)
Binding site163ITP (UniProtKB | ChEBI)
Binding site168-169ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      P167DRAFT_536424

Organism names

  • Taxonomic identifier
  • Strain
    • CCBAS932
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Pezizomycetes > Pezizales > Morchellaceae > Morchella

Accessions

  • Primary accession
    A0A3N4KMP6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region182-224Disordered

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    28,241
  • Last updated
    2019-02-13 v1
  • Checksum
    B21226B320C20897
MSSRTLFFVTSNPGKLAEAKAILSASGVNLESKNVEITEIQGTIEEITRDKAKRAAEQIGGPVIVEDTCLCFDALKGLPGPYVKHFLKEIGTRGLTNMLAAYDDKTAQAVCTFAYCEPGSEPILFEGRTKGKVVRARGEGSFGWDPIFEYEGSTYAEMDSYQKNKISHRFKALQKLTAWLEEKHGGGSGGSGGSAPPPAAPKPVDRRNMGGHDTSSDGGSFFDGFGEEVKSRAINIAGDGMGIRKAAGREWQFDSPDGGRGKY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ML119133
EMBL· GenBank· DDBJ
RPB11770.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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