A0A3M7M7Y7 · A0A3M7M7Y7_9PLEO

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site566-572GTP (UniProtKB | ChEBI)
Active site567Proton acceptor
Binding site567Mg2+ (UniProtKB | ChEBI)
Binding site567-570IMP (UniProtKB | ChEBI)
Binding site592-595IMP (UniProtKB | ChEBI)
Binding site594Mg2+ (UniProtKB | ChEBI)
Binding site594-596GTP (UniProtKB | ChEBI)
Active site595Proton donor
Binding site683IMP (UniProtKB | ChEBI)
Active site694
Binding site697IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site774IMP (UniProtKB | ChEBI)
Binding site789IMP (UniProtKB | ChEBI)
Binding site849-855substrate
Binding site853IMP (UniProtKB | ChEBI)
Binding site855GTP (UniProtKB | ChEBI)
Binding site881-883GTP (UniProtKB | ChEBI)
Binding site963-965GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functiontransmembrane transporter activity
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      GMOD_00000599

Organism names

  • Taxonomic identifier
  • Strain
    • CCB06
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Pyrenophora

Accessions

  • Primary accession
    A0A3M7M7Y7

Proteomes

Subcellular Location

Cytoplasm
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane67-86Helical
Transmembrane106-128Helical
Transmembrane135-155Helical
Transmembrane161-183Helical
Transmembrane195-215Helical
Transmembrane235-254Helical
Transmembrane300-322Helical
Transmembrane342-359Helical
Transmembrane366-387Helical
Transmembrane393-415Helical
Transmembrane427-447Helical
Transmembrane459-481Helical
Transmembrane544-565Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-482Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    975
  • Mass (Da)
    107,449
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    557CDEF02BCD1E39E989B0667921DDB2
MDASVMNNMAESGVAPVGIGQERSPASLEKGEEVIFNEANGSDRSMDSEFSWTEEEETRVRRKLDRVIVPLTTLLYLMCFLDRVNVGNARIQGMAKDLDLNRGVRFNWVTSIFYIVYMFVEVPSNILLKKLGPKYYLPLLVSGFGIVSLCSAFVQSFGGLLVARAFLGVFEGGVMPGLAFFITCFYKRNELLFRIGIYVSAASLAGAFGGLLATVLARIPPWGASTMIIHTWRNIFFFEGLLTVLIGLGAPFLMPGSPEDCWFLTERERMIATKRLVLQGGADENEKTEMHHIKRAMMNITNYFCAVGFFFINITVQGISLFMPTILRDLGWTATKSQLYSVPPYVCACVVAIAVAFISDKTNRRGIYLALFTLPAIAGFSIMRWATDPNVKYGGIFLITIGAFPGGPGFLAWAANNAAGPAVRSVSTAYVVTLGTAGGIVATWTYTSGDAPKYPTGHTINLCGQICVLILACFGIVYCKWENRQRDLGKRDDRLVGKTAAQIRDLGYRHPEFRVPRRESDATRCLIPQATAILQRFNFTPQRLLCFVLYTAISMSVTVVLGSQWGDEGKGKLVDILAQEAKYCCRAQGGNNAGHTIVTNGVKYDFHILPSGLLNPKCINIIGSGCVVHIPSFFNELEALHKQGLKTDGRILISDRAHIVFDLHQLVDACQEAERGSNSIGTTGKGIGPAYAAKVSRIGLRLCDVFDEEEFEEKLRKMAMGYQNTHSHLKYDVQDEIAKFKGFREKLAPYVVDTIPSIKKAIQNKDPILVEGANALMLDIDCGTYPFVTSSNTGIGGVITGLNVDLWSLKEVIGVVKAYTTRVGSGPFPTEQLNEIGEKLQSVGHEFGVTTGRRRRCGWLDLVVVKHSLDINHYTAMNLTKLDILDDFDEIKVGISYSYNGKELEGFPARATVLEGIEVQYATMPGWKTKTTGIKKYDDLPTQAKAYVEFIEEFVGVGVKWIGVGPGRDDTIYKS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE747824
EMBL· GenBank· DDBJ
RMZ70499.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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