A0A3M7M7Y7 · A0A3M7M7Y7_9PLEO
- ProteinAdenylosuccinate synthetase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids975 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Catalytic activity
- IMP + L-aspartate + GTP = N6-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H+
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 566-572 | GTP (UniProtKB | ChEBI) | |||
Active site | 567 | Proton acceptor | |||
Binding site | 567 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 567-570 | IMP (UniProtKB | ChEBI) | |||
Binding site | 592-595 | IMP (UniProtKB | ChEBI) | |||
Binding site | 594 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 594-596 | GTP (UniProtKB | ChEBI) | |||
Active site | 595 | Proton donor | |||
Binding site | 683 | IMP (UniProtKB | ChEBI) | |||
Active site | 694 | ||||
Binding site | 697 | IMP (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 774 | IMP (UniProtKB | ChEBI) | |||
Binding site | 789 | IMP (UniProtKB | ChEBI) | |||
Binding site | 849-855 | substrate | |||
Binding site | 853 | IMP (UniProtKB | ChEBI) | |||
Binding site | 855 | GTP (UniProtKB | ChEBI) | |||
Binding site | 881-883 | GTP (UniProtKB | ChEBI) | |||
Binding site | 963-965 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Molecular Function | adenylosuccinate synthase activity | |
Molecular Function | GTP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | transmembrane transporter activity | |
Biological Process | 'de novo' AMP biosynthetic process | |
Biological Process | IMP metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylosuccinate synthetase
- EC number
- Short namesAMPSase ; AdSS
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Pyrenophora
Accessions
- Primary accessionA0A3M7M7Y7
Proteomes
Subcellular Location
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 67-86 | Helical | |||
Transmembrane | 106-128 | Helical | |||
Transmembrane | 135-155 | Helical | |||
Transmembrane | 161-183 | Helical | |||
Transmembrane | 195-215 | Helical | |||
Transmembrane | 235-254 | Helical | |||
Transmembrane | 300-322 | Helical | |||
Transmembrane | 342-359 | Helical | |||
Transmembrane | 366-387 | Helical | |||
Transmembrane | 393-415 | Helical | |||
Transmembrane | 427-447 | Helical | |||
Transmembrane | 459-481 | Helical | |||
Transmembrane | 544-565 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 68-482 | Major facilitator superfamily (MFS) profile | |||
Sequence similarities
Belongs to the adenylosuccinate synthetase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length975
- Mass (Da)107,449
- Last updated2019-02-13 v1
- MD5 Checksum557CDEF02BCD1E39E989B0667921DDB2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KE747824 EMBL· GenBank· DDBJ | RMZ70499.1 EMBL· GenBank· DDBJ | Genomic DNA |