A0A3M7LYA5 · A0A3M7LYA5_9PLEO

Function

function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.

Catalytic activity

Features

Showing features for binding site.

112021002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site978-983ATP (UniProtKB | ChEBI)
Binding site999AMP (UniProtKB | ChEBI)
Binding site1004AMP (UniProtKB | ChEBI)
Binding site1025-1027AMP (UniProtKB | ChEBI)
Binding site1054-1057AMP (UniProtKB | ChEBI)
Binding site1061AMP (UniProtKB | ChEBI)
Binding site1096ATP (UniProtKB | ChEBI)
Binding site1105-1106ATP (UniProtKB | ChEBI)
Binding site1129AMP (UniProtKB | ChEBI)
Binding site1140AMP (UniProtKB | ChEBI)
Binding site1168ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial intermembrane space
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionRNA binding
Biological ProcessADP biosynthetic process
Biological ProcessAMP metabolic process
Biological ProcessATP metabolic process
Biological Processmitochondrial genome maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase
  • EC number
  • Alternative names
    • ATP-AMP transphosphorylase
    • ATP:AMP phosphotransferase
    • Adenylate kinase cytosolic and mitochondrial
    • Adenylate monophosphate kinase

Gene names

    • Name
      ADK1
    • ORF names
      GMOD_00001045

Organism names

  • Taxonomic identifier
  • Strain
    • CCB06
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Pyrenophora

Accessions

  • Primary accession
    A0A3M7LYA5

Proteomes

Subcellular Location

Cytoplasm, cytosol
Mitochondrion inner membrane
; Single-pass membrane protein
Note: Predominantly mitochondrial.

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain210-302RRM
Region621-640Disordered
Compositional bias625-640Basic and acidic residues
Region998-1027NMPbind
Region1095-1132LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the YME2 family.
Belongs to the adenylate kinase family. AK2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,202
  • Mass (Da)
    132,913
  • Last updated
    2019-02-13 v1
  • MD5 Checksum
    97747DFEDB2C3450BE3FB6B28B4CD696
MHRHVTASGLASCCSTSCAWADADKVGLQAQSPRLVIIIKVLTSCRPSNIGSRGPWTIPRRYVTGLQAGEDKTGHISAGPNEGILFFNNVFPIQIRKVLGLPMPAFVDRLVSPSLSGTDPKTVIERASAKRNLPITATEILPRMREGGAFVKFTHDGSAPTSEIEKTLQAFLREEPVKPWWSPWKRMRAKVVRGRPWVEDLMRLPASRLRVEFVSGEPGAPASEAVELSQEELFQFFRPYGKLGDIVMQPPDSKVLPKFAYLDYTSIGKAIMARNCMHGYLVSEAEGGGAKGTILRLKYEQKIKPRYIRDWILNHPRIVIPIVAALIAGTVAIVFDPIRQFFVKAHITRNFHIEDNKWYQWIKGYATDIMSVGRKHNDSDGMDYIWDDRKESIEQIQTWLMETAETFIIVQGPRGSGKRELVVDQALQDKKVKLVIDCKPIQEARGESATINAAALSVGYRPVFSWMNSISGMIDMAAQGATGVKTGFSETLDSQLSKIWNTTTLALRQIALDTRHKHDKDAHLGDDEWLEAHPERRPIVVIDNFLHKSQEGGIVYDKLAEWAARLTTTNVAHVIFLTNDVAFNKSLSKAMPDRMFRQISLSDCSPEVAKRYVITTLDADVEDDPAPKDGSPKEVPSKHRTDLGELDTCIDLLGGRLTDLEFLSRRIKSGETPTKAVHEIIDQSASEILKMYIFGAEDESGHRSWNAEQAWFLIKELAQKESLRYNEVLIDDILKTGGESVLRALEQAELISIVAGANGRPSVIKPGKPVYYPAFKRLTEDKVLKSRLDLAIFTHLTKIENATIDKCETELLLLSKLRNQPAQTAGRVNYLLTKLMTSQAKVERYEVEMKGLKKVLANGSAPRIGRKGVLSKQARACQQPSNEVPGAPPPIIAASHCHCLTSTASASYLSRIPSHPPSQFSSHSGAMAPITDTVVDDLKSTVNRLEQRIAELENRLSGHGGGAGSTESVRMILMGPPGAGKGTQAPRIKEKFCACHLATGDMLRAQVAAKTPLGREAKKIMDAGGLVSDEIMVNMIKTELENNQECAKGFILDGFPRTVTQAEKLDGMLAATKKPLQHAVELQIDDGLLVSRITGRLVHPASGRSYHKVFNPPKTAMTDDVTGEPLIQRSDDNAETLKKRLSTYHAQTAPVVAYYQKTGIWKPIDASQEPGQVWKSLLKIFDDKAMIAGRTGSLLNKIGLKN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias625-640Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE747810
EMBL· GenBank· DDBJ
RMZ67160.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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