A0A3M7LYA5 · A0A3M7LYA5_9PLEO
- ProteinAdenylate kinase
- GeneADK1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1202 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.
Catalytic activity
- AMP + ATP = 2 ADP
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 978-983 | ATP (UniProtKB | ChEBI) | |||
Binding site | 999 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1004 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1025-1027 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1054-1057 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1061 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1096 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1105-1106 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1129 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1140 | AMP (UniProtKB | ChEBI) | |||
Binding site | 1168 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial intermembrane space | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | RNA binding | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | ATP metabolic process | |
Biological Process | mitochondrial genome maintenance |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Pyrenophora
Accessions
- Primary accessionA0A3M7LYA5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Single-pass membrane protein
Note: Predominantly mitochondrial.
Keywords
- Cellular component
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 210-302 | RRM | |||
Region | 621-640 | Disordered | |||
Compositional bias | 625-640 | Basic and acidic residues | |||
Region | 998-1027 | NMPbind | |||
Region | 1095-1132 | LID | |||
Domain
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence similarities
Belongs to the YME2 family.
Belongs to the adenylate kinase family. AK2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,202
- Mass (Da)132,913
- Last updated2019-02-13 v1
- MD5 Checksum97747DFEDB2C3450BE3FB6B28B4CD696
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 625-640 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KE747810 EMBL· GenBank· DDBJ | RMZ67160.1 EMBL· GenBank· DDBJ | Genomic DNA |