A0A371IQT7 · A0A371IQT7_9FIRM
- ProteinATP-dependent RecD2 DNA helicase
- GenerecD2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids740 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 343-347 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | exodeoxyribonuclease V complex | |
Molecular Function | 5'-3' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | isomerase activity | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA recombination | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RecD2 DNA helicase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Peptostreptococcales > Peptostreptococcaceae > Romboutsia
Accessions
- Primary accessionA0A371IQT7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 116-135 | Helix-hairpin-helix DNA-binding motif class 1 | |||
Domain | 180-199 | Helix-hairpin-helix DNA-binding motif class 1 | |||
Domain | 332-476 | AAA+ ATPase | |||
Sequence similarities
Belongs to the RecD family. RecD2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length740
- Mass (Da)84,171
- Last updated2018-11-07 v1
- MD5 Checksum2F97DAE2D553AC2962A9806C2F7AAC20
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NOJZ02000025 EMBL· GenBank· DDBJ | RDY22828.1 EMBL· GenBank· DDBJ | Genomic DNA |