A0A2Y9PSP7 · A0A2Y9PSP7_DELLE
- ProteinInsulin-induced gene protein
- GeneINSIG2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mediates feedback control of cholesterol synthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | SREBP-SCAP-Insig complex | |
Molecular Function | oxysterol binding | |
Molecular Function | protein sequestering activity | |
Biological Process | cellular response to insulin stimulus | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | cranial suture morphogenesis | |
Biological Process | inner ear morphogenesis | |
Biological Process | middle ear morphogenesis | |
Biological Process | negative regulation of fatty acid biosynthetic process | |
Biological Process | negative regulation of steroid biosynthetic process | |
Biological Process | roof of mouth development | |
Biological Process | SREBP signaling pathway | |
Biological Process | SREBP-SCAP complex retention in endoplasmic reticulum | |
Biological Process | triglyceride metabolic process |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameInsulin-induced gene protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Monodontidae > Delphinapterus
Accessions
- Primary accessionA0A2Y9PSP7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 28-49 | Helical | ||||
Sequence: LMIRGVVLFFIGVFLALVLNLL | ||||||
Transmembrane | 69-88 | Helical | ||||
Sequence: SAWWVPPCCGTASAVIGLLY | ||||||
Transmembrane | 131-148 | Helical | ||||
Sequence: IQLSLTLAALSIGLWWTF | ||||||
Transmembrane | 155-174 | Helical | ||||
Sequence: FGLGIGIAFLATLVTQLLVY | ||||||
Transmembrane | 186-206 | Helical | ||||
Sequence: LYVRSWLPCIFFAGGITMGNI |
Keywords
- Cellular component
Interaction
Subunit
Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)24,906
- Last updated2018-09-12 v1
- ChecksumE92F1C9E32DD72BA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2Y9PTQ4 | A0A2Y9PTQ4_DELLE | INSIG2 | 229 |
Keywords
- Technical term