A0A2T5GCP3 · A0A2T5GCP3_HYDSH

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

137650100150200250300350
TypeIDPosition(s)Description
Binding site71Zn2+ 1 (UniProtKB | ChEBI)
Binding site111Zn2+ 1 (UniProtKB | ChEBI)
Binding site146Zn2+ 1 (UniProtKB | ChEBI)
Binding site146Zn2+ 2 (UniProtKB | ChEBI)
Binding site180Zn2+ 2 (UniProtKB | ChEBI)
Binding site183Zn2+ 3 (UniProtKB | ChEBI)
Binding site215Zn2+ 2 (UniProtKB | ChEBI)
Binding site228Zn2+ 3 (UniProtKB | ChEBI)
Binding site230Zn2+ 3 (UniProtKB | ChEBI)
Binding site260Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      HSCHL_1104

Organism names

Accessions

  • Primary accession
    A0A2T5GCP3

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-265Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    41,215
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    3FC1AF9C4A2281804A6C79273E18B991
MSHPLKIGSHVSFAKKGLLAAAEEAISYGSTTFMVYTGAPQNTVRKPMSEQFVDEGWALARAHGIDEIVVHAPYIINLASPNDDTFRLAVEFLQQEIERTAVLGAREIVVHPGAYTDRDPAYGIRRIVEGLNEVLSVPGEVRIALETMAGKGTEVGRTFEEIAAIIDGVRHPERLSVCFDTCHVHDAGYDLVGDLDGVLEAFDRIIGLERLSVVHLNDSKNPRGAAKDRHAPVGSGWIGYGAIEAVVRHPALAGRPFILETPWIGLDKKAQRPMYEVEIALLSGTLRRRFGAAFCDDVERLAAFFARQGFEPRKTVLDFWTASRAKGADRREPMERLYVLAREAGFGEGLSEEALNHRLIAYFATAARPLAALCAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PEBV01000008
EMBL· GenBank· DDBJ
PTQ53951.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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