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A0A2T3B0W3 · A0A2T3B0W3_AMORE

Function

function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmediator complex
Molecular Functionnickel cation binding
Molecular Functiontranscription coregulator activity
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mediator of RNA polymerase II transcription subunit 8
  • Alternative names
    • Mediator complex subunit 8

Gene names

    • Name
      MED8
    • ORF names
      M430DRAFT_20006

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 22711
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Amorphothecaceae > Amorphotheca

Accessions

  • Primary accession
    A0A2T3B0W3

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the Mediator complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Coiled coil7-34
Region169-190Disordered
Compositional bias176-190Acidic residues

Sequence similarities

Belongs to the Mediator complex subunit 8 family.
Belongs to the UreD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    573
  • Mass (Da)
    63,935
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    6FD0A0B0C544C7550080AAFC3D5B877B
MESPSLRQEDLKALDQTRQRLAQLSRTIASLKGNILQENPLPPWESIQTSAAILSNNMNSIVEHLSRNSDIFNRMVVYPTTNYPGYTQEPLLNQLLQKKLDLSVQSWVDEARAIQDGVTENKEEDMEELWTWAKDWIGQRVATYILEEAGDNYTVEEREQGIENVNRGLRRKLEEEESEDEDEDEEMEGVGVEVTTVGTTSSGEVKYGMEELKKNPDAKVRSVDEILRFATTFQVEFPEFLLLYMNSPFPSSFSAPGEGHLVARLQPQAVSALSKISFQYPLKLISPSPSAHQKSVLVFLLTYGGGLVGGDQVHLVIDVKPGAKLSIVTQGHTKIFKSASRNVITRQKLSVSVEAGAAVCLLPDPVQPFEGSVYEQTQIFTLAKDASLCLLDWVSAGRTARGEDWDLGVWSGRNDVWAAAESGQKPRLLLRDKVLLEGDRAGAEEKALKKKMQGLGIFGTLILKGQLVDSLAAFFLAEFAALPRIGAQDFRSQERQARDSGATLTERELWRRRRLEQEKADGILWSAAKVRGCTVVKFGARTVEGGRTWIGSMIKEETSIERHFGEDSLMCIR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias176-190Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ679012
EMBL· GenBank· DDBJ
PSS17044.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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