A0A2S0MKI6 · A0A2S0MKI6_9RHOB
- ProteinAdenosine 5'-phosphosulfate reductase
- GenecysH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids245 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
Catalytic activity
- [thioredoxin]-disulfide + sulfite + AMP + 2 H+ = adenosine 5'-phosphosulfate + [thioredoxin]-dithiol
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:17359 + CHEBI:456215 + 2 CHEBI:15378 = CHEBI:58243 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 124 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 125 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 205 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 208 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Active site | 231 | Nucleophile; cysteine thiosulfonate intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | adenylyl-sulfate reductase (thioredoxin) activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoadenylyl-sulfate reductase (thioredoxin) activity | |
Biological Process | sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine 5'-phosphosulfate reductase
- EC number
- Short namesAPS reductase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Pukyongiella
Accessions
- Primary accessionA0A2S0MKI6
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for coiled coil, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 1-28 | ||||
Domain | 45-211 | Phosphoadenosine phosphosulphate reductase | |||
Sequence similarities
Belongs to the PAPS reductase family. CysH subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length245
- Mass (Da)27,327
- Last updated2018-07-18 v1
- MD5 ChecksumFB32BA473EB7160EAC894D2513C9EA7A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP027665 EMBL· GenBank· DDBJ | AVO36271.1 EMBL· GenBank· DDBJ | Genomic DNA |