A0A2P5LSJ0 · A0A2P5LSJ0_9HYPH

  • Protein
    Xanthine-guanine phosphoribosyltransferase
  • Gene
    gpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47-485-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site105-1135-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site106Mg2+ (UniProtKB | ChEBI)
Binding site109guanine (UniProtKB | ChEBI)
Binding site109xanthine (UniProtKB | ChEBI)
Binding site109-113GMP (UniProtKB | ChEBI)
Binding site151-152GMP (UniProtKB | ChEBI)
Binding site152guanine (UniProtKB | ChEBI)
Binding site152xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      CTY25_09810

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DS2.3.33
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Methylobacteriaceae > Methylobacterium

Accessions

  • Primary accession
    A0A2P5LSJ0

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-162Phosphoribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    172
  • Mass (Da)
    18,730
  • Last updated
    2018-05-23 v1
  • MD5 Checksum
    B4EBA1A8A647A0237FA14E0D8156E39D
MNAAPAPQAIPEKAFPVSWDQFHRDARMLAWRLAGSGPFSSIVCITRGGLVPAAIIARELELRMIETVCIASYHSYTEQGGLEVLKGIDHVITGTEGGKGVLVLDDLVDTGKTVKVVREMLPNAHFATVYAKPLGRPLVDTFITEVSQDSWIYFPWDMGFAFQPPIMKGAAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PERO01000019
EMBL· GenBank· DDBJ
PPD14628.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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