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A0A2L1JI19 · A0A2L1JI19_9PSED

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    hflB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

163650100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site194-201ATP (UniProtKB | ChEBI)
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site494Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      AWV77_00235
      , C9383_19300
      , CYL20_27425
      , F7R03_11315

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Ps006
    • MAB3
    • LMG 23076
    • CCUG 51524
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A2L1JI19
  • Secondary accessions
    • A0A120EAK7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane98-120Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain186-325AAA+ ATPase
Region598-636Disordered

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    636
  • Mass (Da)
    69,089
  • Last updated
    2018-04-25 v1
  • MD5 Checksum
    D5249E2C94A92B9C7AA4C6C95692175F
MAKNLILWLIIAAVLVTVMNNFSSPNEPQTLNYSDFIQQVKDGKVERVAVDGYVITGKRNDGDSFKTIRPAIQDNGLIGDLVDNHVVVEGKQPEQQSIWTQLLVASFPILVIIAVFMFFMRQMQGGAGGKGGPMSFGKSKARLLSEDQVKTTLADVAGCDEAKEEVGELVEFLRDPGKFQRLGGRIPRGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKHAPCIIFIDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFEMNDGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDIRGREQILKVHMRKVPMGDDVAPAVIARGTPGFSGADLANLVNEASLFAARTGKRIVEMKEFELAKDKIMMGAERKTMVMSEKEKQNTAYHEAGHAIVGRVVPEHDPVYKVSIIPRGRALGVTMFLPEEDRYSLSKRALISQICSLYGGRIAEEMTLGFDGVTTGASNDIMRASQIARNMVTKWGLSEKLGPLMYAEEEGEVFLGRGGGGQNASFSGETAKLIDSEVRSIIDQCYGTAKQILTDNRDKLDAMADALMKYETIDADQIDDIMAGRAPREPRDWEGGSGTSGTPPVVQNERPETPIGGPAADH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP025494
EMBL· GenBank· DDBJ
AVE08120.1
EMBL· GenBank· DDBJ
Genomic DNA
VZPQ01000005
EMBL· GenBank· DDBJ
KAB0567575.1
EMBL· GenBank· DDBJ
Genomic DNA
LRMR01000001
EMBL· GenBank· DDBJ
KWU52963.1
EMBL· GenBank· DDBJ
Genomic DNA
PYWX01000053
EMBL· GenBank· DDBJ
PTC24403.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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