A0A2K6F7R1 · A0A2K6F7R1_PROCO

Function

function

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.

Catalytic activity

  • sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
    EC:2.3.1.15 (UniProtKB | ENZYME | Rhea)
  • dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • sn-glycerol 3-phosphate + octadecanoyl-CoA = 1-octadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism.
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.

GO annotations

AspectTerm
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionglycerol-3-phosphate O-acyltransferase activity
Biological Processactivated T cell proliferation
Biological Processactivation-induced cell death of T cells
Biological Processacyl-CoA metabolic process
Biological ProcessCDP-diacylglycerol biosynthetic process
Biological Processdefense response to virus
Biological Processfatty acid homeostasis
Biological Processfatty acid metabolic process
Biological Processglycerol-3-phosphate metabolic process
Biological Processnegative regulation of activation-induced cell death of T cells
Biological Processphosphatidylglycerol biosynthetic process
Biological Processphospholipid homeostasis
Biological Processpositive regulation of activated T cell proliferation
Biological Processpositive regulation of multicellular organism growth
Biological Processregulation of cytokine production
Biological Processresponse to glucose
Biological Processtriglyceride biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate acyltransferase 1, mitochondrial
  • EC number

Gene names

    • Name
      GPAM

Organism names

Accessions

  • Primary accession
    A0A2K6F7R1

Proteomes

Subcellular Location

Mitochondrion outer membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain183-316Phospholipid/glycerol acyltransferase
Region394-414Disordered
Compositional bias398-414Basic and acidic residues

Sequence similarities

Belongs to the GPAT/DAPAT family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    787
  • Mass (Da)
    88,963
  • Last updated
    2018-03-28 v1
  • Checksum
    CE653DFAFBABC2E7
MDESALNLGMIDVSYLPNSSEYSVGRCKHTSEEWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFVQERDVHKGMFATNVAENVLNSSRVQEAIAEVAAELNPDGSPQQQSKAINRVKKKAKRILQEMVATVSPSMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATEMNLPLIFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDILYRALLNGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNTIPDILIIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQRPVSAPLSLEQALLPAILPSRPSDAADEGRDTSVSESRNATDESLRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCITITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMESIIACSLYAVLNKRGSGGPAGNPPSLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEQDDQEDTSPGLAEQHWDKKLPEPLTWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFIHNFSGPIPEPEYLQKLHKYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRVSILELSSTFLPQGNRQKLLEYILSFVVL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias398-414Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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