A0A2I1EUC9 · A0A2I1EUC9_9GLOM
- ProteinSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids338 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55-58 | CoA (UniProtKB | ChEBI) | |||
Binding site | 81 | CoA (UniProtKB | ChEBI) | |||
Binding site | 134-136 | CoA (UniProtKB | ChEBI) | |||
Binding site | 198 | substrate; ligand shared with subunit beta | |||
Active site | 291 | Tele-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex (ADP-forming) | |
Molecular Function | nucleotide binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | succinate-CoA ligase (GDP-forming) activity | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Glomerales > Glomeraceae > Rhizophagus
Accessions
- Primary accessionA0A2I1EUC9
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
Heterodimer of an alpha and a beta subunit.
Structure
Sequence
- Sequence statusComplete
- Length338
- Mass (Da)35,776
- Last updated2018-02-28 v1
- MD5 Checksum4A62C003A6ACB26B6DED33DD76A0B163
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAGKOT010000034 EMBL· GenBank· DDBJ | CAB5375266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LLXH01000885 EMBL· GenBank· DDBJ | PKC62231.1 EMBL· GenBank· DDBJ | Genomic DNA |