A0A2I0NGD2 · A0A2I0NGD2_9EURY

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13substrate
Binding site37Mg2+ (UniProtKB | ChEBI)
Active site66Proton acceptor
Binding site66Mg2+ (UniProtKB | ChEBI)
Binding site67substrate
Binding site142-145substrate
Binding site163substrate
Binding site168-169substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      CVV36_09210

Organism names

Accessions

  • Primary accession
    A0A2I0NGD2

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    182
  • Mass (Da)
    19,803
  • Last updated
    2018-02-28 v1
  • Checksum
    D8C87390768CD6EA
MRKIIFVTGNSHKVAEASYIMSGIGIKVEQNNCGYPELQDENLEKIAGFGAQWAANKLNCEVMVDDSGLFIEALGGFPGPYSAYVFDTLGNEKILKLMEGETNRKAVFRCVIGYCKPGYEPRVFSGEVAGVIAGGIRGNGGFGYDPILEVGGITFGEMPDEEKNSLSHRYLALVNFAGWLEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PGYG01000072
EMBL· GenBank· DDBJ
PKL53033.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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