A0A2I0NFV9 · A0A2I0NFV9_9EURY
- ProteinNucleoside diphosphate kinase
- Genendk
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids150 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 9 | ATP (UniProtKB | ChEBI) | |||
Binding site | 57 | ATP (UniProtKB | ChEBI) | |||
Binding site | 85 | ATP (UniProtKB | ChEBI) | |||
Binding site | 91 | ATP (UniProtKB | ChEBI) | |||
Binding site | 102 | ATP (UniProtKB | ChEBI) | |||
Binding site | 112 | ATP (UniProtKB | ChEBI) | |||
Active site | 115 | Pros-phosphohistidine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | CTP biosynthetic process | |
Biological Process | GTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNucleoside diphosphate kinase
- EC number
- Short namesNDK ; NDP kinase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Candidatus Methanoperedenaceae
Accessions
- Primary accessionA0A2I0NFV9
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length150
- Mass (Da)16,823
- Last updated2018-02-28 v1
- Checksum824E1FB73F819CE9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PGYG01000087 EMBL· GenBank· DDBJ | PKL52866.1 EMBL· GenBank· DDBJ | Genomic DNA |