A0A2G4JDH2 · A0A2G4JDH2_9ARCH

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Features

Showing features for binding site, site.

144050100150200250300350400
Type
IDPosition(s)Description
Binding site123-125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site237Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      CK527_05430
      , EXS75_02355

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Baikal-G1
    • Baikal-deep-G181
  • Taxonomic lineage
    Archaea > Nitrososphaerota > Nitrososphaeria > Nitrosopumilales > Nitrosopumilaceae > Nitrosarchaeum

Accessions

  • Primary accession
    A0A2G4JDH2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue238N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-396Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    440
  • Mass (Da)
    48,842
  • Last updated
    2018-01-31 v1
  • Checksum
    82877EE5812AC918
MVKSTNKESYNKIFSKLKEHHKLFENSIPLIASENITSPAVREAIISDFGNRYAEGWPGERVYAGCRYIDDVEFECMNLAKKLFKAKFADVRSISGVVANLVVYSAFSNPGDIMIAPSIPAGGHISHGKKEHSGTAGLVHGLEIEFYPFDAESMTIDVDKTKQKVEELKKIGRLPKIAMFGGSLFLFPHPVKELADFLKSFDIHINYDAAHVAGLIAGGKFQDPLREGADTVTMSTHKTLFGPQGGLVLGSEKHEDGIKKATFPGLTSSHHIHHMAGKAIAFAEALEFGKDYAIQIIKNAKVFAQSLNDAGFKVLGESRGFTESHQVAVNVLEYSDGGKVEVDLEKANIIVNRQLIPGDIKAGRNYFHPGGIRLGVSEITRLGMKQDEMKEIALYIKQVVIDKKDPKKILLKVKKFRENYQKVHYCFDNKLGAYEYIKLR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
SICX01000015
EMBL· GenBank· DDBJ
MSV26439.1
EMBL· GenBank· DDBJ
Genomic DNA
NSIR01000005
EMBL· GenBank· DDBJ
PHY08792.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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