A0A238FKK5 · A0A238FKK5_9BASI

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-17ITP (UniProtKB | ChEBI)
Binding site49Mg2+ (UniProtKB | ChEBI)
Binding site61ITP (UniProtKB | ChEBI)
Binding site77Mg2+ (UniProtKB | ChEBI)
Binding site77-78ITP (UniProtKB | ChEBI)
Binding site153-156ITP (UniProtKB | ChEBI)
Binding site176ITP (UniProtKB | ChEBI)
Binding site181-182ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      BQ2448_3961

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Pucciniomycotina > Microbotryomycetes > Microbotryales > Microbotryaceae > Microbotryum

Accessions

  • Primary accession
    A0A238FKK5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    21,152
  • Last updated
    2017-11-22 v1
  • Checksum
    49F4199998F33AF6
MASSATKILFVTGNANKLKEVRSILAGGSSSSSSSFSIDLDSKALDLPEIQGTTSEVARAKVKAAAEIIGGPCITEDTALAFTALKGLPGPYIKHFLDSLGHEGLNKMLAGFPDKSATAICTFAYSAGPGSEPLLFEGKTEGKIVEARGPTHFGWDPIFEADASGQTYAEMDGQEKNKISHRYRALDKLRAFLLAQGQQP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMSP01000009
EMBL· GenBank· DDBJ
SCV72424.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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