A0A1Z4F442 · A0A1Z4F442_9MYCO

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site81substrate
Binding site220-222substrate
Binding site229Mn2+ (UniProtKB | ChEBI)
Binding site249Mn2+ (UniProtKB | ChEBI)
Binding site271substrate
Binding site272-277GTP (UniProtKB | ChEBI)
Active site273
Binding site296Mn2+ (UniProtKB | ChEBI)
Binding site387-389substrate
Binding site389GTP (UniProtKB | ChEBI)
Binding site420GTP (UniProtKB | ChEBI)
Binding site515-518GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      MSTE_04663

Organism names

Accessions

  • Primary accession
    A0A1Z4F442

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-240Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain245-604Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    606
  • Mass (Da)
    67,301
  • Last updated
    2017-09-27 v1
  • Checksum
    683484619F9E1134
MTAATIPGLDNAPTKHAGLLAWVREVAELTQPDRVVFADGSDEEFERVSQQLVDAGTFQRLNSEKHPNSFLALSDPSDVARVESRTYICSEREEDAGPTNNWVDPTEMRETMTELFRGSMRGRTMWVVPFCMGPLGAEDPKLGVELTDSEYVVASMRVMTRMGAAALEKLGDDGFFVKALHSIGAPLEPGQEDVPWPCNDTKYITHFPESREIWSYGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYVAAAFPSACGKTNLAMIQPTIPGWRAETLGDDIAWMRFGKDGRLYAVNPEFGFFGVAPGTNWSSNPNAMKTIEAGNTVFTNVARTDDNDVWWEGLEGEPEHLIDWKGQDWILRETETKAAHPNSRYCTPMSQCPILAPEWDDPQGVPISAILFGGRRKTTVPLVTEARDWQHGVFIGGTLGSEQTAAAEGKVGTVRRDPMAMLPFMGYHVGDYLNHWINVGKQADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWIVDRIEHRANGVSTPIGTVPGVEDLDLAGLDVEEADVAEALAVHNDEWQAELPLIEEWFEFIGDKLPTGVKDEFDALKQRLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018165
EMBL· GenBank· DDBJ
BAX99954.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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