A0A1Z4F2E8 · A0A1Z4F2E8_9MYCO

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-18NAD+ (UniProtKB | ChEBI)
Binding site16NADPH (UniProtKB | ChEBI)
Binding site17NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site53NADPH (UniProtKB | ChEBI)
Binding site111NADPH (UniProtKB | ChEBI)
Binding site111sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site111substrate
Binding site139sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site143NAD+ (UniProtKB | ChEBI)
Binding site143NADPH (UniProtKB | ChEBI)
Active site194Proton acceptor
Binding site194sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site247sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site257sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258NAD+ (UniProtKB | ChEBI)
Binding site258NADPH (UniProtKB | ChEBI)
Binding site258sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258-259substrate
Binding site259sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site282NADPH (UniProtKB | ChEBI)
Binding site284NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA_2
    • Synonyms
      gpsA
    • ORF names
      MSTE_04087

Organism names

Accessions

  • Primary accession
    A0A1Z4F2E8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-163Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain183-323Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    36,248
  • Last updated
    2017-09-27 v1
  • Checksum
    859F7632916E8E6B
MAALREPQVVVLGGGSWGTTVASIVARRSPTLQWARSPETVADINERHRNSRYLSDEVELTESLRATSDLHEAIEQADVVIMGVPSHSFREVLTEIGQSLRPWVPIVSLVKGLEQGSRMRMSQIIEEVLPGHPAGILAGPNIAKEVARGYAAAGVVAMPDQHQAARLGELFRTSRFRVYSTNDVVGVEMAGALKNVFAIASGMGYAIGIGENTRAMVIARALREMTKLGVAMGGNPETFPGLAGLGDLIVTCTSASSRNRHVGEEIGKGKTIDEIIESMNQVAEGVKASSVVMTLADEYGIQMPIAREVDGVINHGSTVEQAYRGLMAATPGHEVHGTGF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018165
EMBL· GenBank· DDBJ
BAX99381.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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