A0A1Z4F051 · A0A1Z4F051_9MYCO

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site40ATP (UniProtKB | ChEBI)
Binding site103-104ATP (UniProtKB | ChEBI)
Binding site133-136ATP (UniProtKB | ChEBI)
Binding site134Mg2+ (UniProtKB | ChEBI); catalytic
Site135Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site156-158substrate; ligand shared between dimeric partners; in other chain
Active site158Proton acceptor
Binding site193substrate; ligand shared between dimeric partners
Binding site200-202substrate; ligand shared between dimeric partners; in other chain
Binding site253substrate; ligand shared between dimeric partners; in other chain
Binding site297substrate; ligand shared between dimeric partners
Binding site303-306substrate; ligand shared between dimeric partners; in other chain

GO annotations

AspectTerm
Cellular Component6-phosphofructokinase complex
Molecular Function6-phosphofructokinase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionfructose-6-phosphate binding
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmonosaccharide binding
Biological Processcanonical glycolysis
Biological Processfructose 1,6-bisphosphate metabolic process
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      pfkA
    • ORF names
      MSTE_03303

Organism names

Accessions

  • Primary accession
    A0A1Z4F051

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-328Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    373
  • Mass (Da)
    39,942
  • Last updated
    2017-09-27 v1
  • Checksum
    0087899D2187CABE
MGGVHAERPAASTEGVVALPPGDVTGMMGPMRIGVLTGGGDCPGLNAVIRAVVRTCANRYDSQVVGFQDGWRGLLENRRIQLANDDRNDRLLTKGGTVLGTARTNPDKLRAGLDQIKQTLDDNGIDVLIPIGGEGTLTAASWLADENVPVVGVPKTIDNDIDCTDVTFGFDTALTIATDAIDRLHSTAESHQRVMLVEVMGRHAGWIALHSGLASGAHMTLIPEVPYDVEEVCRLIKGRFQRGDSHFICVVAEGAKPAEGSMELRDGGIDEFGHQRFTGVAQQLGVEIEKRINKEVRTTVLGHVQRGGTPTPFDRVLATRFGVNAADAAHAGEYGVMVSLRGQDIGRVPLSEATRHLKLVPKNRYEDAAAFFG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP018165
EMBL· GenBank· DDBJ
BAX98605.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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