A0A1X0NHV5 · A0A1X0NHV5_9TRYP

Function

function

Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionthymine dioxygenase activity
Biological Processbase J metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    thymine dioxygenase
  • EC number

Gene names

    • ORF names
      TM35_000461610

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0NHV5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Monomer. Binds to DNA as a monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain122-2782OGFeDO JBP1/TET oxygenase
Domain411-573Thymine dioxygenase JBP1 DNA-binding

Sequence similarities

Belongs to the TET family. JBP1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    824
  • Mass (Da)
    93,288
  • Last updated
    2017-07-05 v1
  • Checksum
    FBCB6B5CF80BD0B4
MPKPIKRAPDAAENAFMGKLKKEHLEGINFSSRSIPRTAEEIEKAYAEAVKKHPFHDNADHTVDFYGASVFRDSKGKVCGVLLPGALPAFAASMAANVLRPAASKTSLRSNMYGGQSPLSGIAGYFDYRGSPVELKCRKTSFTCEHIQSWPDVFPMIDYISAVYKAIFPKQWAAQNDAIPDVVRIHGSPFSTLTINQRFRTASHTDAGDFDMGYGLLAVLEGNFKGLSLALDDFGVCFRMQPRDVLLFNTHFFHSNTEPEINNPNDNWDRLTCVFYYRAALGEPGCVAEYARRLAHAKEIGASPPPVVDTIVQKDNGDNFNKPAPVFSSSLSPFNGAAGICCLRKCASKLLRLHELLLGKPELEILLFGEPLFTNDGLPHRPMEQLIPVHPPVVIKTPNIGWCSDTSTLLKLAKEKQYLFEEKNLENEVGPELMKIWMRSRNLWLNLVKIDWDRLLQNNPDRTNFTWNNTSAMNTAFFDLCEVAKQVMLGLLNKEAPSKEEELSFWVLFAAHLNYACVHENGMPCEAISMRKLNVKLKDFHFGGTRYLKDMPPEEQQRRLERRRQIEEARRNGVSAREKQVSGWLQNDSFDYQQEDRILNFKKNGWISPEENVRNLKLKPCEETTKATGLTEHINLLVVLPRPAPPGRCAKPKKPSMTLEEVKRLMMNPAAQRLLAGECRNVLPASPLTFNDVTITFIFDGDEIGDSHFDFIILQHVIAAIESDEEAELRVNYWASHAKHCIFLIETDLLDRRHYVLQNEVRVKYQEVAENCFSTLHAAAYSTESIHLRRTPFFTDLNKGNNVEMRYKFKGSPLNTVAFLLSSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000046
EMBL· GenBank· DDBJ
ORC84342.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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