A0A1T4JZ99 · A0A1T4JZ99_9FIRM
- ProteinTyrosine--tRNA ligase
- GenetyrS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids405 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic activity
- tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 34 | L-tyrosine (UniProtKB | ChEBI) | |||
Binding site | 167 | L-tyrosine (UniProtKB | ChEBI) | |||
Binding site | 171 | L-tyrosine (UniProtKB | ChEBI) | |||
Binding site | 230 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | RNA binding | |
Molecular Function | tyrosine-tRNA ligase activity | |
Biological Process | tyrosyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Eubacteriaceae > Eubacterium
Accessions
- Primary accessionA0A1T4JZ99
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Motif | 39-48 | 'HIGH' region | |||
Motif | 227-231 | 'KMSKS' region | |||
Domain | 324-400 | Tyrosine--tRNA ligase SYY-like C-terminal | |||
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length405
- Mass (Da)45,724
- Last updated2017-05-10 v1
- ChecksumE2DF66DCB15EC43B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FUXA01000003 EMBL· GenBank· DDBJ | SJZ35493.1 EMBL· GenBank· DDBJ | Genomic DNA |