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A0A1S2WUS6 · A0A1S2WUS6_9GAMM

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      KX00_1096

Organism names

  • Taxonomic identifier
  • Strain
    • TX076608
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Francisellaceae > Francisella

Accessions

  • Primary accession
    A0A1S2WUS6

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-24Helical
Transmembrane50-72Helical
Transmembrane79-97Helical
Transmembrane103-123Helical
Transmembrane135-162Helical
Transmembrane168-188Helical
Transmembrane220-238Helical
Transmembrane258-279Helical
Transmembrane291-311Helical
Transmembrane317-337Helical
Transmembrane349-372Helical
Transmembrane392-412Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-415Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    47,437
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    3793DD2625EBC1EA2C35D51CA588DD73
MKSTKYSLVIGWSIWCIAAIFYGLDYFQHTAPSVLVKPIATTMQVGIEDIAYIMSIYFPIYAISQVPAGILLDKYGSKIMLSISCLVMSLGILLFSYDPNLVTMLIGRILIAIGSAVAFIGTLKVAADVLPERAFPIAVGLTNTIGVLGGIFGQIFLNYLVILHGWQFALVLIGYFGIFWSIIIIVLLKSPNIDNTSINNYKFKYLSFAQSLKLLLNKKLWFLALYAGLMVGIVVNSFSELYDVLFLEQAYGLSQHLAAKVSIMMFIGIAVGGPSHGFIASLFGEKRIWMLVCNIMTILAFSVVIIFADFISVDNLYIIFFVIGFSVSSMLLVFSVVEEIFPPQIKATALAIVNMVIGLCGAIFQYLISYISVYLNGGPLTGEINTNVFDRAFIYLIIPLLLSTIIIFTIVVEKYRTREISLKRLSKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRXS01000006
EMBL· GenBank· DDBJ
OIN83925.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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