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A0A1R3GNU4 · A0A1R3GNU4_9ROSI

  • Protein
    Inosine triphosphate pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site19-24ITP (UniProtKB | ChEBI)
Binding site47Mg2+ (UniProtKB | ChEBI)
Binding site59ITP (UniProtKB | ChEBI)
Binding site75Mg2+ (UniProtKB | ChEBI)
Binding site75-76ITP (UniProtKB | ChEBI)
Binding site151-154ITP (UniProtKB | ChEBI)
Binding site174ITP (UniProtKB | ChEBI)
Binding site179-180ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      COLO4_34082

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • cv. O-4
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Grewioideae > Apeibeae > Corchorus

Accessions

  • Primary accession
    A0A1R3GNU4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    201
  • Mass (Da)
    22,151
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    1024E52A2EFCCB9509BE770D0AB9CAA4
MASLAAKAVLLSRPVTFVTGNAKKLEEVKDILGQSIPFQSLKLDLPELQGEPEEISKEKARLAALQVRGPVLVEDTCLCFNALKGLPGPYIKWFLQKIGHEGLNNLLMAYEDKSAYALCAFSFALGPDVEPITFLGKTPGKIVPARGPNDFGWDPIFQPDGYDQTYAEMPKEEKNKISHRYKALAMVKSHFAEAGYEFSAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AWUE01022071
EMBL· GenBank· DDBJ
OMO59726.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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