A0A1R3GNU4 · A0A1R3GNU4_9ROSI
- ProteinInosine triphosphate pyrophosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids201 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Catalytic activity
- ITP + H2O = IMP + diphosphate + H+
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 19-24 | ITP (UniProtKB | ChEBI) | |||
Binding site | 47 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 59 | ITP (UniProtKB | ChEBI) | |||
Binding site | 75 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 75-76 | ITP (UniProtKB | ChEBI) | |||
Binding site | 151-154 | ITP (UniProtKB | ChEBI) | |||
Binding site | 174 | ITP (UniProtKB | ChEBI) | |||
Binding site | 179-180 | ITP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dITP diphosphatase activity | |
Molecular Function | ITP diphosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | XTP diphosphatase activity | |
Biological Process | deoxyribonucleoside triphosphate catabolic process | |
Biological Process | nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine triphosphate pyrophosphatase
- EC number
- Short namesITPase ; Inosine triphosphatase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Grewioideae > Apeibeae > Corchorus
Accessions
- Primary accessionA0A1R3GNU4
Proteomes
Subcellular Location
Interaction
Structure
Sequence
- Sequence statusComplete
- Length201
- Mass (Da)22,151
- Last updated2017-04-12 v1
- MD5 Checksum1024E52A2EFCCB9509BE770D0AB9CAA4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AWUE01022071 EMBL· GenBank· DDBJ | OMO59726.1 EMBL· GenBank· DDBJ | Genomic DNA |