A0A1Q9ULX7 · A0A1Q9ULX7_9PSEU

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1025-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site1065-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1085-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site128-1365-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site132orotate (UniProtKB | ChEBI)
Binding site160orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      BJF85_08410

Organism names

  • Taxonomic identifier
  • Strain
    • CUA-673
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Saccharomonospora

Accessions

  • Primary accession
    A0A1Q9ULX7

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain51-165Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    186
  • Mass (Da)
    19,442
  • Last updated
    2017-04-12 v1
  • Checksum
    D5B1A323AE4D3C6F
MATPSLDQAAKSELARLVTELCVVHGKVTLASGAEADYYIDLRRATLHHAAAPLIGTLLRQLTADWNYVAVGGLTLGADPVATSMLHSAASDGMVLDAFVVRKNLKEHGMQRRIEGMEVAGQRVLAVEDTSTTGGSVLTAVEALGEAGATVVGVATVVDRGTAAREAIEAAGLEYRYLLDLDDLGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MKKE01000084
EMBL· GenBank· DDBJ
OLT38707.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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