A0A1Q9ULX7 · A0A1Q9ULX7_9PSEU
- ProteinOrotate phosphoribosyltransferase
- GenepyrE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids186 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
Catalytic activity
- orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 102 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 103 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 106 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 108 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 128-136 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 132 | orotate (UniProtKB | ChEBI) | |||
Binding site | 160 | orotate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | orotate phosphoribosyltransferase activity | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | pyrimidine nucleobase biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotate phosphoribosyltransferase
- EC number
- Short namesOPRT ; OPRTase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Saccharomonospora
Accessions
- Primary accessionA0A1Q9ULX7
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 51-165 | Phosphoribosyltransferase | |||
Sequence similarities
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length186
- Mass (Da)19,442
- Last updated2017-04-12 v1
- ChecksumD5B1A323AE4D3C6F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MKKE01000084 EMBL· GenBank· DDBJ | OLT38707.1 EMBL· GenBank· DDBJ | Genomic DNA |