A0A1M5JBN9 · A0A1M5JBN9_9FIRM

Function

function

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86Nucleophile
Active site203
Active site205

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionglutaminase activity
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase subunit PurQ
  • EC number
  • Short names
    FGAM synthase
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase subunit I
      (FGAR amidotransferase I
      ; FGAR-AT I
      )
    • Glutaminase PurQ
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • Phosphoribosylformylglycinamidine synthase subunit I

Gene names

    • Name
      purQ
    • ORF names
      SAMN02745221_00032

Organism names

Accessions

  • Primary accession
    A0A1M5JBN9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.

Protein-protein interaction databases

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    233
  • Mass (Da)
    25,576
  • Last updated
    2017-03-15 v1
  • Checksum
    480A5E293E8FE43C
MRFGIVVFPGSNCDADCYHVIKDVMQEEACYIWHKETDLQGVDAVILPGGFSYGDYLRAGAIARFSPVMSAVKEFAARGGLVIGICNGFQILLEAGLLPGAMLRNRSLKFICDQVHLKVNRTDTPFSHLFAPGEVVKIPIAHGEGNYYCPPEILEELKANRQILFTYCSPQGEVSDEYNPNGSLANIAGIINKEGNVLGMMPHPERCSEEILGGTDGFKIFASMIKWAKEASR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FQWY01000002
EMBL· GenBank· DDBJ
SHG37423.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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