A0A1L1YNX0 · A0A1L1YNX0_9FLOR
- ProteinCytochrome c oxidase subunit 1
- Genecox1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids460 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Rhodophyta > Florideophyceae > Rhodymeniophycidae > Gracilariales > Gracilariaceae > Gracilaria
Accessions
- Primary accessionA0A1L1YNX0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-49 | Helical | |||
Transmembrane | 70-92 | Helical | |||
Transmembrane | 112-137 | Helical | |||
Transmembrane | 149-176 | Helical | |||
Transmembrane | 196-220 | Helical | |||
Transmembrane | 232-256 | Helical | |||
Transmembrane | 268-291 | Helical | |||
Transmembrane | 303-324 | Helical | |||
Transmembrane | 344-362 | Helical | |||
Transmembrane | 383-401 | Helical | |||
Transmembrane | 421-441 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length460
- Mass (Da)50,969
- Last updated2017-03-15 v1
- MD5 Checksum8B8675EA770C96B43210E1C1A1E6C6C1
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 460 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP010044 EMBL· GenBank· DDBJ | AKN80290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010045 EMBL· GenBank· DDBJ | AKN80291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010046 EMBL· GenBank· DDBJ | AKN80292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010047 EMBL· GenBank· DDBJ | AKN80293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010048 EMBL· GenBank· DDBJ | AKN80294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010049 EMBL· GenBank· DDBJ | AKN80295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010050 EMBL· GenBank· DDBJ | AKN80296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010051 EMBL· GenBank· DDBJ | AKN80297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010052 EMBL· GenBank· DDBJ | AKN80298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010053 EMBL· GenBank· DDBJ | AKN80299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010054 EMBL· GenBank· DDBJ | AKN80300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010055 EMBL· GenBank· DDBJ | AKN80301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010056 EMBL· GenBank· DDBJ | AKN80302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010057 EMBL· GenBank· DDBJ | AKN80303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010058 EMBL· GenBank· DDBJ | AKN80304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010059 EMBL· GenBank· DDBJ | AKN80305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010061 EMBL· GenBank· DDBJ | AKN80307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010062 EMBL· GenBank· DDBJ | AKN80308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP010063 EMBL· GenBank· DDBJ | AKN80309.1 EMBL· GenBank· DDBJ | Genomic DNA |