A0A1J1I7K4 · A0A1J1I7K4_9DIPT

  • Protein
    Phosphodiesterase
  • Gene
    putative cGMP-dependent 3'
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

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Type
IDPosition(s)Description
Active site301Proton donor
Binding site301-305AMP (UniProtKB | ChEBI)
Binding site305Zn2+ 1 (UniProtKB | ChEBI)
Binding site343Zn2+ 1 (UniProtKB | ChEBI)
Binding site344AMP (UniProtKB | ChEBI)
Binding site344Zn2+ 1 (UniProtKB | ChEBI)
Binding site344Zn2+ 2 (UniProtKB | ChEBI)
Binding site451AMP (UniProtKB | ChEBI)
Binding site451Zn2+ 1 (UniProtKB | ChEBI)
Binding site502AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrial outer membrane
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentsynaptic membrane
Molecular Function3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Biological ProcesscAMP-mediated signaling
Biological ProcesscGMP catabolic process
Biological ProcesscGMP-mediated signaling
Biological Processnegative regulation of cAMP-mediated signaling
Biological Processnegative regulation of cGMP-mediated signaling
Biological Processpositive regulation of gene expression
Biological Processregulation of mitochondrion organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      putative cGMP-dependent 3'
    • ORF names
      CLUMA_CG007900

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Chironomoidea > Chironomidae > Clunio

Accessions

  • Primary accession
    A0A1J1I7K4

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_501333488517-553Phosphodiesterase

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain222-545PDEase

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    553
  • Mass (Da)
    63,766
  • Last updated
    2017-02-15 v1
  • Checksum
    2C5300CEE3528FC4
MTFVLTFILFRSYVLGHLLTAFELYEEKRVRFQTQTLLQVARRLLGKIGDLGQLLRGVMAEARELAKAERCSLFLLDKDTGELVSKVFDGNAVTQRKSSREIRISGHQGIAGHVAQTGKLLNIHNAYQHPLFYKGIDEQTGFKTRNILCFPICDEERVIGVAQLCNKIDGFHFDKCDEETATAFSVYCGISIMHSMVHKRVQKAEARYKLSQELLLFHMKVPDIDVRNCLNSTYLHSAEEKFPTFDTFEFCPRDVDEHSSIYLCIKMFKDLDFIALFKIPEEKLARFLLLVQKGYRNTPYHNWFHAFSVAHFSYVCMKNLRLMERGIITKLQGLSFLISCLCHDLDHRGFNNSYMTQSGSQLARLYSSEGSINERHHLSQAICILNDPGSKILDSLSTEQFMESIDYLRELILATDLANHFRIFKQLKTLNPENIVDNQRMLLSLLMTCCDLNDQIKMWTTVHSVAELVYTEFFAQGDLERQMGLNPNLMMDRKKACIPALQIEFLDTVVTPTFEIFVQIFPEKSDFLQTISINREHWVEVKEKETTKNGSSC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CVRI01000038
EMBL· GenBank· DDBJ
CRK94393.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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