A0A1H7CXT9 · A0A1H7CXT9_9BURK

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      SAMN05518853_104440

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • OK202
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax

Accessions

  • Primary accession
    A0A1H7CXT9

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-43Helical
Transmembrane55-76Helical
Transmembrane88-111Helical
Transmembrane117-135Helical
Transmembrane147-168Helical
Transmembrane174-196Helical
Transmembrane217-240Helical
Transmembrane260-282Helical
Transmembrane294-313Helical
Transmembrane319-337Helical
Transmembrane349-368Helical
Transmembrane388-408Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-410Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    43,107
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    B9264B8E6AC57AC905E74EF968433F1A
MPASTGPDGDATPLTLRSAWVMVLALCAGVALSQAFRTVGAIMASPLQADFHLSAQALGIFSGAFHFAFGAMQLFMGIGIDLHGVRRTVLVAFPIAIAGALLSAVSSSYLMLVAGQALIGVGCAPAFLVCTVFIARHFPAARFATVSGMVLAIGGLGMLVTGTPLAWLVQAYSWRAGFVVLAVAAALAWLAIWRWVHEPASAVPQTKESIPEAIRQFGALFAMPHTLGIIVLGAVTYAAFISLRGLWLGPLMMERHGYSLVQSGNVALAVSVISLFGAPLFGRLDRDGAGRRRWIVICALGYAALFALIAVLHSAWLDITGMVLIGVLSGFIVWQYADVRGAYPTTLTGRAMAVFTMAMFLGVALMQWGTGVAASVASAHGGDPLTAVLATIAVLLVVGIAAFAWLPAPKSTAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNZJ01000004
EMBL· GenBank· DDBJ
SEJ91550.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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