A0A1H6XAH4 · A0A1H6XAH4_9BURK

  • Protein
    Multifunctional fusion protein
  • Gene
    cmk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site253-phosphoshikimate (UniProtKB | ChEBI)
Binding site25phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site263-phosphoshikimate (UniProtKB | ChEBI)
Binding site303-phosphoshikimate (UniProtKB | ChEBI)
Binding site110phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site138phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site1883-phosphoshikimate (UniProtKB | ChEBI)
Binding site1893-phosphoshikimate (UniProtKB | ChEBI)
Binding site1903-phosphoshikimate (UniProtKB | ChEBI)
Binding site190phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site2173-phosphoshikimate (UniProtKB | ChEBI)
Active site340Proton acceptor
Binding site3403-phosphoshikimate (UniProtKB | ChEBI)
Binding site3673-phosphoshikimate (UniProtKB | ChEBI)
Binding site371phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site415phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site442phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site467-475ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-phosphoshikimate 1-carboxyvinyltransferase activity
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processphosphorylation
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    3-phosphoshikimate 1-carboxyvinyltransferase
  • EC number
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate synthase
      (EPSP synthase
      ; EPSPS
      )
  • Recommended name
    Cytidylate kinase
  • EC number
  • Short names
    CK
  • Alternative names
    • Cytidine monophosphate kinase
      (CMP kinase
      )

Gene names

    • Name
      cmk
    • Synonyms
      aroA
    • ORF names
      SAMN05518853_1011086

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • OK202
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax

Accessions

  • Primary accession
    A0A1H6XAH4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-451Enolpyruvate transferase
Domain463-672Cytidylate kinase

Sequence similarities

Belongs to the EPSP synthase family.
Belongs to the cytidylate kinase family. Type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    682
  • Mass (Da)
    72,569
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    8F4C25A05C2CB3F78963FB3E576FA45F
MFSTAFLDLPPLAGAAGTVRLPGSKSISNRVLLLAALASGTTTIHDLLDSDDTRVMLDALRALGCGVVRDAADTTDATDAAGGSTLRVTGLGGQLKPGGALLALFLGNAGTAMRPLTAALSLLGGEFELSGVPRMHERPIGDLVDALTQLGCRIDYLGNPGYPPLRIHPVPHGELMLDTPIRVRGDVSSQFLTALLLALPLAAAGDIVIEVVGELISKPYIEITLNLLARFGIQVRRDGWERFTIPAGSSYSSPGDIHVEADASSASYFIALGAIATGVLGKNGIRIEGVGADSIQGDIRFIDAARQMGALVDSGPNWLEIRRGAWPLKAIDLDANHIPDAAMTLAVMALYADGPTTLRNIASWRVKETDRIDAMANELRKLGAAVEAGPDFIRVHPLAQAGWRPASIRTYDDHRVAMCFSLAAFNPAGVPVRMLDPHCVAKTFPDYFETLFSVAEAAEVPVICIDGPTASGKGTLAAEVARLLGYHYLDSGSLYRVTGLAMRRAGLTAETQHEAQIAAMAAALPLQFTEGKVLLAGEDVSEDIRTEAAGMDASRVSTLPAVRAALLALQQRFRELPGLVADGRDMGTVIFPDATLKVFLTASAAQRAERRHKQLISKGISTTLDSLRSDLEARDARDSSRSVAPLKPAQDARHLDNSQLSIEQSIDQVLDWWQEIQPFKPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNZJ01000001
EMBL· GenBank· DDBJ
SEJ24474.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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