A0A1H6XAH4 · A0A1H6XAH4_9BURK
- ProteinMultifunctional fusion protein
- Genecmk
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids682 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Catalytic activity
- 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphateThis reaction proceeds in the forward direction.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 25 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 25 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 26 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 30 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 110 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 138 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 188 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 189 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 190 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 190 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 217 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Active site | 340 | Proton acceptor | |||
Binding site | 340 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 367 | 3-phosphoshikimate (UniProtKB | ChEBI) | |||
Binding site | 371 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 415 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 442 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 467-475 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-phosphoshikimate 1-carboxyvinyltransferase activity | |
Molecular Function | ATP binding | |
Molecular Function | CMP kinase activity | |
Molecular Function | dCMP kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | pyrimidine nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended name3-phosphoshikimate 1-carboxyvinyltransferase
- EC number
- Alternative names
- Recommended nameCytidylate kinase
- EC number
- Short namesCK
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax
Accessions
- Primary accessionA0A1H6XAH4
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 16-451 | Enolpyruvate transferase | |||
Domain | 463-672 | Cytidylate kinase | |||
Sequence similarities
Belongs to the EPSP synthase family.
Belongs to the cytidylate kinase family. Type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length682
- Mass (Da)72,569
- Last updated2017-11-22 v1
- MD5 Checksum8F4C25A05C2CB3F78963FB3E576FA45F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FNZJ01000001 EMBL· GenBank· DDBJ | SEJ24474.1 EMBL· GenBank· DDBJ | Genomic DNA |