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A0A1H5KXA8 · A0A1H5KXA8_9PSED

  • Protein
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Gene
    coaBC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site159Proton donor
Binding site278CTP (UniProtKB | ChEBI)
Binding site288CTP (UniProtKB | ChEBI)
Binding site307-310CTP (UniProtKB | ChEBI)
Binding site325CTP (UniProtKB | ChEBI)
Binding site339CTP (UniProtKB | ChEBI)
Binding site343CTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentphosphopantothenoylcysteine decarboxylase complex
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular Functionphosphopantothenate--cysteine ligase activity
Molecular Functionphosphopantothenoylcysteine decarboxylase activity
Biological Processcoenzyme A biosynthetic process
Biological Processpantothenate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Alternative names
    • DNA/pantothenate metabolism flavoprotein
    • Phosphopantothenoylcysteine synthetase/decarboxylase
      (PPCS-PPCDC
      )

Including 2 domains:

  • Recommended name
    Phosphopantothenoylcysteine decarboxylase
  • EC number
  • Short names
    PPC decarboxylase
    ; PPC-DC
  • Alternative names
    • CoaC
  • Recommended name
    Phosphopantothenate--cysteine ligase
  • EC number
  • Alternative names
    • CoaB
    • Phosphopantothenoylcysteine synthetase
      (PPC synthetase
      ; PPC-S
      )

Gene names

    • Name
      coaBC
    • ORF names
      AWV77_07650
      , C9383_08655
      , CYL20_16940
      , F7R03_08185
      , SAMN04490198_2442

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Ps006
    • BS3265
    • MAB3
    • LMG 23076
    • CCUG 51524
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A1H5KXA8
  • Secondary accessions
    • A0A0X7K841

Proteomes

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-190Phosphopantothenoylcysteine decarboxylase
Domain7-169Flavoprotein
Domain186-370DNA/pantothenate metabolism flavoprotein C-terminal
Region191-402Phosphopantothenate--cysteine ligase

Sequence similarities

In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    402
  • Mass (Da)
    42,844
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    BA73E5FE24D950A19CF6FE40D8B2132A
MQRLYRKRIVLGVGGGIAAYKSAELVRRLLDQGAEVRVVMTRGGSEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWADLVLIAPATADLIARLAQGIADDLLTTLVLATDATVAIAPAMNQAMWRDPATQANTQLLQSRGLKVFGPASGSQACGDVGMGRMLEATDLALCAAECFQHLALTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVHLPTPDRVTRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPQKLKKDPTNGDGLLLQMVRNPDILASIATRPDRPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRELHATLFAQTSKGKIARQLISFIAQRLNQV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP025494
EMBL· GenBank· DDBJ
AVE06166.1
EMBL· GenBank· DDBJ
Genomic DNA
VZPQ01000003
EMBL· GenBank· DDBJ
KAB0568563.1
EMBL· GenBank· DDBJ
Genomic DNA
LRMR01000006
EMBL· GenBank· DDBJ
KWU51898.1
EMBL· GenBank· DDBJ
Genomic DNA
PYWX01000029
EMBL· GenBank· DDBJ
PTC28606.1
EMBL· GenBank· DDBJ
Genomic DNA
FNUA01000002
EMBL· GenBank· DDBJ
SEE69426.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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