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A0A1H0ZW22 · A0A1H0ZW22_9HYPH

Function

function

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site26-304-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site584-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site59Mg2+ (UniProtKB | ChEBI)
Binding site78Mg2+ (UniProtKB | ChEBI)
Binding site974-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site1264-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine (UniProtKB | ChEBI)
Binding site1552-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate (UniProtKB | ChEBI)
Binding site175-1762-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionthiamine-phosphate diphosphorylase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine-phosphate synthase
  • EC number
  • Short names
    TP synthase
    ; TPS
  • Alternative names
    • Thiamine-phosphate pyrophosphorylase
      (TMP pyrophosphorylase
      ; TMP-PPase
      )

Gene names

    • Name
      thiE
    • ORF names
      SAMN04515695_0800

Organism names

  • Taxonomic identifier
  • Strain
    • Tun.PHSC04-5.I4
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Stappiaceae > Pseudovibrio

Accessions

  • Primary accession
    A0A1H0ZW22

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-178Thiamine phosphate synthase/TenI

Sequence similarities

Belongs to the thiamine-phosphate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    22,059
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    A08772E11C00F6ED9E9C1A003B99345A
MERFYLIVGHVDWIERLVPHGVKLVQLRIKDEPEKEVHRQVKLARELCAHLGAQLVVNDYWQMALELGCDFVHLGQEDMDTADFAALRNAGIRFGLSTHDEGELERALSFNPEYIALGPVYPTLLKKMKWAPQGLDHVTRWKSIVGSTPLVAIGGLTPERLPDVFAAGADSAAVVTDIQRAADPVLRTKEWVEACRP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNLB01000004
EMBL· GenBank· DDBJ
SDQ31674.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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