A0A1F8DW42 · A0A1F8DW42_9BACT

Function

function

Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site192Mg2+ (UniProtKB | ChEBI)
Binding site252Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionphospho-N-acetylmuramoyl-pentapeptide-transferase activity
Molecular FunctionUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
  • EC number
  • Alternative names
    • UDP-MurNAc-pentapeptide phosphotransferase

Gene names

    • Name
      mraY
    • ORF names
      A2935_04030

Organism names

Accessions

  • Primary accession
    A0A1F8DW42

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-32Helical
Transmembrane65-89Helical
Transmembrane101-123Helical
Transmembrane135-155Helical
Transmembrane175-192Helical
Transmembrane199-218Helical
Transmembrane224-241Helical
Transmembrane248-268Helical
Transmembrane327-349Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    350
  • Mass (Da)
    38,528
  • Last updated
    2017-02-15 v1
  • Checksum
    CF0D042B304B4918
MLSLHIIRILILTGISFFVALILTPFVTRFLYRIKAGKQIGREGSAPVFFSLHQKKAGTPTMGGLIIWITVVGLSIIFFLLGVVFDGMWSYLNFVDRAETYLPIIAMLIAALLGLADDVLANLKKGTNAGGGVPVKFKLLLYLLIGFVGAYWFYYKLGWTVFSIPFVGTLEIQGWYIPIFIFVIAATAFSANETDGLDGLLGGTSLFTFASLAVVAFVLGRYDLAAFSCVVIGALLAFLWFNIYPARFFMGDTGSMALGITMGVIALLTNTALFLPFFAPILVLESASVIIQMISKKIFKKKIFISTPIHHHFEALGWPESRVTMRFWIIAAISNGIGLVLFFLSRIIVQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MGIS01000019
EMBL· GenBank· DDBJ
OGM92656.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help