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A0A1F8DTV2 · A0A1F8DTV2_9BACT

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

161350100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site204-211ATP (UniProtKB | ChEBI)
Binding site426Zn2+ (UniProtKB | ChEBI); catalytic
Active site427
Binding site430Zn2+ (UniProtKB | ChEBI); catalytic
Binding site502Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      A2935_01775

Organism names

Accessions

  • Primary accession
    A0A1F8DTV2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane110-133Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain196-335AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    613
  • Mass (Da)
    67,616
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    FB1BC28E65ADBD5B146B8977FFD01182
MKSSKIIKNLFVTILVFISVILLFSSVYTAGEQPQIISLSELAQKIQADEVRSLTVEENTVTATLSDDSITETHKEAETSLTETLGQFGVSSEQLSQIAITVQEPSGWKFWSGILLPTLIPILVIGFLFWFMFRQARSGASQALSFGKSNIRLFAPFKDRITFADVAGATEAKQELVEVVDFLKNSKKYLDLGAQIPRGVLLLGPPGTGKTLLARAVAGEAQVPYFHISASEFVEMFVGVGASRTRDAFQTAKKAAPSILFIDEIDAIGRERGAGLGGGHDEREQTLNQILVEMDGFDKEAQVVVLAATNRPDILDPALLRPGRFDRRVILDLPDLKDREAILKIHGRNKKLAKDIDYTRIAQRTPGFSGADLANLMNEGAILAARKNKKVVAQDDLYEAVEKVILGPERRSRVFGKKEKEITAYHEAGHALVAASLKDADPVHKVSIIARGQAGGYTLKLPIEDRYLKTRKQFLADLAVTFGGYATEEIMFKDISTGASNDLSVASEITRKMVSKYGMSEKFGPITFGKTQELIFLGREISNEKNYSESVAAEIDKEVSSIIEKAYNAAKKIITKRKSALEAIAKELMKKETLERDDFDALIKQFKFKLIEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MGIS01000024
EMBL· GenBank· DDBJ
OGM92053.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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